Relationships of serum levels of endocan, interleukin-1α and YKL-40 with disease severity and prognosis in children with recurrent respiratory infection

WANG Aiying; ZHANG Xiaopeng; ZHANG Xin; FAN Lin

doi:10.7619/jcmp.20243261

Journal of Clinical Medicine in Practice > 2025 > 29(6): 7-12. > DOI: 10.7619/jcmp.20243261

WANG Aiying, ZHANG Xiaopeng, ZHANG Xin, FAN Lin. Relationships of serum levels of endocan, interleukin-1α and YKL-40 with disease severity and prognosis in children with recurrent respiratory infection[J]. Journal of Clinical Medicine in Practice, 2025, 29(6): 7-12. DOI: 10.7619/jcmp.20243261

Citation:

PDF (976 KB)

Relationships of serum levels of endocan, interleukin-1α and YKL-40 with disease severity and prognosis in children with recurrent respiratory infection

1.
Department of Blood Transfusion, the Eighth People′s Hospital of Qingdao of Shandong Province, Qingdao, Shandong, 266100
2.
Qingdao Central Hospital of Kangfu University, Qingdao Central Medical Group, Qingdao, Shandong, 266000
3.
Department of Clinical Laboratory, the Third People′s Hospital of Qingdao of Shandong Province, Qingdao, Shandong, 266029

More Information

Received Date: July 30, 2024
Revised Date: September 26, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the correlations of serum levels of endothelial cell-specific molecule-1 (ESM-1, also known as endocan), interleukin (IL)-1α, and human chondroglycan protein-39 (also known as YKL-40) with disease severity and prognosis in children with recurrent respiratory infections (RRI).
Methods
A total of 86 children with RRI were prospectively enrolled as case group and divided into mild (37 cases), moderate (31 cases), and severe (18 cases) groups based on disease severity, and divided into good prognosis (64 cases) and poor prognosis (22 cases) groups based on prognosis. Additionally, 94 healthy children who underwent physical examinations during theYKL-40 were measured using enzyme-linked immunosorbent assay (ELISA) in all children. Spearman′s correlation analysis was used to assess the correlation between serum levels of endocan, IL-1α, and YKL-40 and disease severity in children with RRI. Multivariate Logistic regression analysis was conducted to explore the factors influencing the prognosis of children with RRI. Receiver operating characteristic (ROC) curves were used to evaluate the predictive value of serum endocan, IL-1α, and YKL-40 for the prognosis of children with RRI.
Results
The serum levels of endocan, IL-1α, and YKL-40 in the case group were higher than those in the control group (P < 0.05). The serum levels of endocan, IL-1α, and YKL-40 in the moderate and severe groups were higher than those in the mild group, and the levels in the severe group were higher than those in the moderate group (P < 0.05). The serum levels of endocan, IL-1α, and YKL-40 in the poor prognosis group were higher than those in the good prognosis group (P < 0.05). Serum levels of endocan, IL-1α, and YKL-40 were significantly positively correlated with disease severity in children with RRI (r=0.407, 0.493, 0.452, respectively; P < 0.001). Multivariate Logistic regression analysis showed that serum endocan(OR=1.412), IL-1α(OR=1.583), and YKL-40(OR=1.259) were independent influencing factors for the prognosis of children with RRI (P < 0.05). The ROC curve showed that the area under the curve for the combined prediction of poor prognosis in children with RRI by serum endocan, IL-1α, and YKL-40 was 0.925, which was significantly larger than that for endocan, IL-1α, and YKL-40 alone.
Conclusion
Serum levels of endocan, IL-1α, and YKL-40 are closely related to disease severity and prognosis in children with RRI, and their combined detection has high predictive value for the prognosis of children with RRI.

FullText(HTML)

References (26)

References

[1]	PAI S I, WASSERMAN I, JI Y D, et al. Pulmonary manifestations of chronic HPV infection in patients with recurrent respiratory papillomatosis[J]. Lancet Respir Med, 2022, 10(10): 997-1008. doi: 10.1016/S2213-2600(22)00008-X
[2]	CARDINALE F, LA T F, TRICARICO L G, et al. Why do some children get sick with recurrent respiratory infections[J]. Curr Pediatr Rev, 2024, 20(3): 203-215. doi: 10.2174/1573396320666230912103056
[3]	赵淑景, 马志平, 张金彪, 等. 反复呼吸道感染患儿外周血单个核细胞中TLR2、TLR4表达情况与Th1/Th2免疫应答的关系[J]. 国际检验医学杂志, 2024, 45(6): 663-666.
[4]	BRAIDO F, MELIOLI G, NICOLINI G, et al. Prevention of recurrent respiratory tract infections: a literature review of the activity of the bacterial lysate Lantigen B[J]. Eur Rev Med Pharmacol Sci, 2023, 27(16): 7756-7767.
[5]	GUZEL D, KALKAN E A, EREN F, et al. Can serum endocan levels be used as an early prognostic marker for endothelial dysfunction in COVID-19?[J]. Angiology, 2022, 73(5): 438-444. doi: 10.1177/00033197211050446
[6]	CAO Y J, HU X T, ZHOU C, et al. Increased IL-1α expression in chronic rhinosinusitis with nasal polyps[J]. Eur Arch Oto Rhino Laryngol, 2023, 280(3): 1209-1217.
[7]	SÁNCHEZ-DÍEZ S, MUNOZ X, OJANGUREN I, et al. YKL-40 and KL-6 levels in serum and sputum of patients diagnosed with hypersensitivity pneumonitis[J]. J Allergy Clin Immunol Pract, 2022, 10(9): 2414-2423. doi: 10.1016/j.jaip.2022.06.031
[8]	国家呼吸系统疾病临床医学研究中心, 中华医学会儿科学分会呼吸学组, 中国医师协会呼吸医师分会儿科呼吸工作委员会, 等. 儿童呼吸道合胞病毒感染诊断、治疗和预防专家共识[J]. 中华实用儿科临床杂志, 2020, 35(4): 241-250.
[9]	中华医学会儿科学分会呼吸学组, 《中华儿科杂志》编辑委员会. 反复呼吸道感染的临床概念和处理原则[J]. 中华儿科杂志, 2008, 46(2): 108-110.
[10]	王天宜, 蒋婷婷, 汤鹤, 等. 25(OH)D3在反复呼吸道感染患儿中的表达水平及与TB淋巴细胞亚群的相关性[J]. 热带医学杂志, 2023, 23(11): 1551-1553, 1592.
[11]	ZHANG W, HUANG J, LIU H, et al. Whether immunostimulants are effective in susceptible children suffering from recurrent respiratory tract infections: a modeling analysis based on literature aggregate data[J]. J Clin Pharmacol, 2022, 62(2): 245-253.
[12]	许华, 熊丽丹, 文鹏. 单核细胞/中性粒细胞检测、颗粒凝集法、胶体金法诊断儿童肺炎支原体感染的价值比较[J]. 实用临床医药杂志, 2020, 24(17): 19-23. doi: 10.7619/jcmp.202017005
[13]	胡静. 肺炎支原体肺炎患儿机体免疫细胞功能变化研究[J]. 实用临床医药杂志, 2020, 24(22): 60-62. doi: 10.7619/jcmp.202022017
[14]	MERCANTEPE F, BAYDUR S S, CUMHUR C M, et al. Relationship between serum endocan levels and other predictors of endothelial dysfunction in obese women[J]. Angiology, 2023, 74(10): 948-957. doi: 10.1177/00033197221129358
[15]	OZER Y S, BALABAN Y F, OREM C, et al. Elevated circulating endocan levels are associated with increased levels of endothelial and inflammation factors in postprandial lipemia[J]. J Clin Med, 2023, 12(4): 1267.
[16]	叶云虹, 王念, 聂诗雨, 等. NLRP3炎症小体、高迁移率族蛋白B1与内皮细胞特异性分子-1诊断脓毒症合并急性呼吸窘迫综合征的临床价值[J]. 中国医刊, 2022, 57(5): 512-516.
[17]	LEVY C, DOGNON N, NORMANDIN S, et al. Assessment of plasma endocan for the prediction of mortality in COVID-19 patients undergoing veno-venous ECMO: a pilot study[J]. Med Intensiva, 2023, 47(1): 51-54.
[18]	彭贵鑫. Endocan及血浆纤维蛋白原对AECOPD严重程度评估及预后价值的临床研究[D]. 苏州: 苏州大学, 2022.
[19]	IKOMA K, TAKAHAMA M, KIMISHIMA A, et al. Oridonin suppresses particulate-induced NLRP3-independent IL-1α release to prevent crystallopathy in the lung[J]. Int Immunol, 2022, 34(10): 493-504.
[20]	WANG Y S, WANG J, ZHENG W J, et al. Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design[J]. Immunity, 2023, 56(7): 1485-1501.
[21]	佳莉娟, 徐祖超, 朱娜, 等. 肺结核分枝杆菌感染与趋化因子MCP-1、MIF和炎症因子IL-6、IL-1α、IL-1β水平的相关性分析[J]. 医药论坛杂志, 2023, 44(16): 73-77.
[22]	RENIERIS G, KARAKIKE E, GKAVOGIANNI T, et al. IL-1 mediates tissue-specific inflammation and severe respiratory failure in COVID-19[J]. J Innate Immun, 2022, 14(6): 643-656.
[23]	QI L L, PENG G Y, TANG W T, et al. The mechanism of lung tissue YKL-40 promoting the interstitial transformation of alveolar epithelial cells and its effect on TGF-β1 level in mice with idiopathic pulmonary fibrosis[J]. Cell Mol Biol: Noisy-le-grand, 2023, 69(4): 172-178.
[24]	SHI G, LI M, E Y, et al. Prognostic performance of serum YKL-40 for one-year clinical outcomes in acute ischemic stroke[J]. Aging: Albany NY, 2023, 15(4): 1199-1209.
[25]	缪治永, 冉晶晶, 牟大超, 等. YKL-40促进Ⅱ型肺泡上皮细胞A549炎症因子的表达[J]. 四川大学学报: 医学版, 2023, 54(5): 954-958.
[26]	郝淑娟, 赵颖, 马彤辉, 等. 血清YKL-40、EGF表达水平与肺炎新生儿病情的关系及其对不良预后的预测价值分析[J]. 东南大学学报: 医学版, 2022, 41(5): 609-614.

Cited By

Get Citation

PDF

XML

Article views (32) PDF downloads (7)

Turn off MathJax

Article Contents

Abstract

References

Relationships of serum levels of endocan, interleukin-1α and YKL-40 with disease severity and prognosis in children with recurrent respiratory infection

Abstract

References

Catalog

Export File

Citation

Format

Content