Effects of Bushen Jiedu Formula combined with auricular pressure by coxherb seeds on cancer-induced pain and quality of life in patients with advanced colorectal cancer
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摘要:目的
探讨补肾解毒方联合耳穴压豆对晚期结直肠癌患者癌性疼痛及生活质量的影响。
方法将2019年6月—2023年5月本院收治的120例晚期结直肠癌患者纳入本研究，并将其随机分为2组。对照组(60例)行常规护理和“三阶梯”镇痛法干预疼痛，观察组(60例)在对照组基础上行补肾解毒方联合耳穴压豆治疗, 2组均持续治疗1个月。比较2组患者治疗前后数字评分量表(NRS)评分、治疗效果、生活质量量表(QOL)评分、不良反应发生情况，检测血清中P物质(SP)、β内啡肽(β-EP)、前列腺素E2(PGE2)水平。
结果治疗后，观察组NRS评分以及SP、β-EP和PGE2水平分别为(2.23±0.64) 分、(11.51±2.64) ng/mL、(78.64±9.46) ng/L、(41.90±6.32) ng/L, 分别低于对照组的(2.87±1.25)分、(15.64±2.42) ng/mL、(101.29±11.26) ng/L、(78.63±10.17) ng/L, 差异有统计学意义(P < 0.05); 观察组治疗总有效率为90.00%, QOL评分为(51.92±5.66)分，分别高于对照组的75.00%、(43.58±5.12) 分，差异有统计学意义(P < 0.05)。2组不良反应发生率比较，差异无统计学意义(P>0.05)。
结论补肾解毒方联合耳穴压豆可明显改善晚期结直肠癌患者的癌性疼痛，提高生活质量，且安全性较好。
Abstract:ObjectiveTo explore the effects of Bushen Jiedu Formula combined with auricular pressure by coxherb seeds on cancer pain and quality of life in patients with advanced colorectal cancer.
MethodsA total of 120 patients with advanced colorectal cancer admitted to our hospital from June 2019 to May 2023 were included in the study, and were randomly divided into two groups. The control group (60 cases) received routine nursing care and the "three-step" analgesic method to intervene pain, while the observation group (60 cases) received treatment with Bushen Jiedu Formula combined with auricular pressure by coxherb seeds on the basis of the control group. Both groups were treated for one month. The Numerical Rating Scale (NRS) score, the therapeutic effect, the quality of life (QOL) score and the occurrence of adverse reactions were compared between the two groups before and after treatment, and the levels of substance P (SP), β-endorphin (β-EP) and prostaglandin E2(PGE2) of the two groups before and after treatment in serum were detected.
ResultsAfter treatment, the NRS score and the levels of SP, β-EP and PGE2 in the observation group were (2.23±0.64), (11.51±2.64) ng/mL, (78.64±9.46) ng/L and (41.90±6.32) ng/L, respectively, which were lower than (2.87±1.25), (15.64±2.42) ng/mL, (101.29±11.26) ng/L and (78.63±10.17) ng/L, respectively of the control group (P < 0.05). The total effective rate and QOL score of the observation group were 90.00% and (51.92±5.66), which were higher than 75.00% and (43.58±5.12), respectively of the control group (P < 0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).
ConclusionThe combination of Bushen Jiedu Formula and auricular pressure by coxherb seeds can obviously improve the cancer-induced pain of patients with advanced colorectal cancer, improve their quality of life, and have good safety.
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表 1 2组NRS评分比较(x ± s)
分 时点 对照组(n=60) 观察组(n=60) 治疗前 5.53±1.34 5.37±1.12 治疗后 2.87±1.25* 2.23±0.64*# 与治疗前比较, *P < 0.05; 与对照组比较, #P < 0.05。 
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表 2 2组患者治疗效果比较[n(%)]
组别 完全缓解 部分缓解 轻度缓解 无效 总有效 对照组(n=60) 7(11.67) 23(38.33) 15(25.00) 15(25.00) 45(75.00) 观察组(n=60) 11(18.33) 26(43.33) 17(28.33) 6(10.00) 54(90.00)* 与对照组比较, *P < 0.05。
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表 3 2组患者治疗前后生活质量量表评分比较(x ± s)
分 时点 对照组(n=60) 观察组(n=60) 治疗前 23.60±3.74 24.23±3.68 治疗后 43.58±5.12* 51.92±5.66*# 与治疗前比较, *P < 0.05; 与对照组比较, #P < 0.05。
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表 4 2组治疗前后血清SP、β-EP、PGE2水平比较(x ± s)
指标 时点 对照组(n=60) 观察组(n=60) SP/(ng/mL) 治疗前 22.39±3.19 21.76±2.53 治疗后 15.64±2.42* 11.51±2.64*# β-EP/(ng/L) 治疗前 137.45±14.53 136.44±14.56 治疗后 101.29±11.26* 78.64±9.46*# PGE2/(ng/L) 治疗前 198.31±20.57 199.64±20.35 治疗后 78.63±10.17* 41.90±6.32*# SP: 血清P物质; β-EP: β内啡肽; PGE2: 前列腺素E2。与治疗前比较, *P < 0.05; 与对照组比较, #P < 0.05。
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表 5 2组不良反应发生情况比较[n(%)]
组别 恶心呕吐 头晕 腹痛腹泻 便秘 对照组(n=60) 12(20.00) 19(31.67) 10(16.67) 4(6.67) 联合组(n=60) 14(23.33) 16(26.67) 7(11.67) 6(10.00)
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