Clinical analysis of radiotherapy combined with TP regimen chemotherapy in treating 86 cases of esophageal squamous carcinoma
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摘要: 目的 探讨紫杉醇与顺铂同步化疗联合放疗对食管癌的可行性和近期疗效.方法 对126例食管鳞癌患者进行前瞻随机分组研究,其中单纯放疗组40例,放化同步治疗综合组86例.放疗采用常规分割方式,总剂量50～64 Gy,放化疗同步治疗组在上述放疗的同时加用化疗,化疗采用TP方案.计算2组总生存率、放化疗毒副反应,以及死亡原因分析.结果 放化疗组和单纯放疗组的1年生存率分别为76.7％和71.8％.同期放化疗可提高KPS评分90、N1期亚组的1年生存率.放化疗同步治疗组Ⅲ～Ⅳ级骨髓抑制、食管炎发生率高于单纯放疗组,但差异无统计学意义,其他急性毒副反应、晚期副反应发生率相似.2组的局部复发率分别为48.8％ 、66.7％,远处转移率分别为16.3％、12.8％.结论 同期放化疗可提高患者总生存率、KPS评分90和N1期亚组的生存率,降低区域失败率,但未能降低远处转移率,且Ⅲ～Ⅳ级骨髓抑制、急性食管炎发生率增加.
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Choi J Y, Jang K T, Shim Y M. Prognostic significance of vascular endothelial growth factor expression and microvessel density in esophageal squamous cell carcinoma:comparison with positron emission tomography [J]. Annals of Surgical Oncology, 2006(8):1054. 殷蔚伯, 谷铣之. 肿瘤放射治疗学 [M]. 北京:中国协和医科大学出版社, 2002.609. Kubo N, Morimoto J, Tanaka H. Concurrent chemoradiotherapy with nedaplatin and 5-fluorouraeil (5-fu) for locally advanced squamous call carcinoma of the esophagus [J]. Gan to Kagaku Ryoho(Japanese Journal of Cancer and Chemotherapy), 2009, (12):1997. Janmaat M L, Gallegos-Ruiz M I, Rodrigue J A. Predictive factors for outcome in a phase Ⅱ study of gefitinib in second-line treatment of advanced esophageal cancer patients [J]. Journal of Clinical Oncology, 2006, (10):1612. Wainberg Z A, Lin L S, DiCarlo B. Phase Ⅱi trial of modified FOLFOX6 and erlotinib in patients with metastatic or advanced adenocarcinoma of the oesophagus and gastro-oesophageal junction [J]. British Journal of Cancer, 2011(6):760. Shimada H, Matsubara H, Shimtofi. Phase Ⅰ/Ⅱ adenoviral p53 gene therapy for chemoradiation resistant advanced esophageal squamous cell carcinoma [J]. Cancer Science, 2006(6):554. Wong R K, Malthaner R. Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alonein localized carcinoma of the esophagus [J]. Cochrane Database of Systematic Reviews, 2006(1):CD002092. 吴芳, 陈述嫦, 卢致辉. 紫杉醇酯质体或紫杉醇联合5-氟尿嘧啶一线治疗晚期胃癌的临床疗效分析 [J]. 中华肿瘤杂志, 2010(3):234.
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