奥美拉唑预防急性心肌梗塞发生应激性溃疡的临床研究

孙秀芳

孙秀芳. 奥美拉唑预防急性心肌梗塞发生应激性溃疡的临床研究[J]. 实用临床医药杂志, 2012, (24): 34-36.
引用本文: 孙秀芳. 奥美拉唑预防急性心肌梗塞发生应激性溃疡的临床研究[J]. 实用临床医药杂志, 2012, (24): 34-36.
SUN Xiufang. Clinical research of omeprazole on preventing stress ulcers induced by acute myocardial infarction[J]. Journal of Clinical Medicine in Practice, 2012, (24): 34-36.
Citation: SUN Xiufang. Clinical research of omeprazole on preventing stress ulcers induced by acute myocardial infarction[J]. Journal of Clinical Medicine in Practice, 2012, (24): 34-36.

奥美拉唑预防急性心肌梗塞发生应激性溃疡的临床研究

详细信息
  • 中图分类号: R632.1

Clinical research of omeprazole on preventing stress ulcers induced by acute myocardial infarction

  • 摘要: 目的 观察行PCI术及氯吡格雷治疗的急性心肌梗死患者联用奥美拉唑情况,比较不同组别应激性溃疡的发生率,为急性心肌梗死患者预防应激性溃疡合理用药提供临床研究依据.方法 本研究共纳入急性心肌梗死成功行PCI术的患者306例,按照使用奥美拉唑情况分为2组:非PPIs组154例、PPIs组152例,比较2组患者住院期间应激性溃疡消化道出血事件的发生率.结果 2组患者住院期间应激性溃疡发生率及消化道大出血发生率有显著差异(P<0.05).结论 急性心肌梗死患者在病程早期(1周内)及时联用质子泵抑制剂(奥美拉唑)可以有效预防发生应激性溃疡引起的消化道出血,尤其是消化道大出血的发生.
  • Yusuf S, Reddy S, CunPuu S. AnandS Global burden of cardiovascular diseases, Part Ⅰ:general considerations, the epidemiologic transition, risk factors, and impact of urbanization [J]. Circulation, 2001, (22):2746.
    Rogacka R, Chieffo A, Michev I. Dual antiplatelet therapy after percutaneous coronary intervention with stent implantation in patients taking chronic oral anticoagulation [J]. JACC Cardiovasc Interv, 2008(1):56.
    《中华医学杂志》编辑委员会. 应激性溃疡防治建议 [J]. 中华医学杂志, 2002, (14):1000.doi: 10.3760/j:issn:0376-2491.2002.14.027.
    Judkins M P. Selective coronaryar teriography:a percutaneous tranfem oral technic [J]. Radiology, 1967(5):815.
    黄仁伦. 应激性溃疡发生机制研究进展 [J]. 国际医药卫生导报, 2006, (22):120.doi: 10.3760/cma.j.issn.1007-1245.2006.22.059.
    韩肇木. 急性心肌梗死合并上消化道出血51例临床分析 [J]. 现代诊断与治疗, 2008(3):172.
    Tang EW, Wong CK, Herbisonp. Global Registry of Acute Coronary Events (GRACE) hospital discharge risk score accurately prediets long-term mortality post acute coronary syndrome [J]. American Heart Journal, 2007(1):29.
    Eikelboom J W, Mehta S R, Anand S S. Adverse impact of bleeding on Prognosis in patients with acute coronary syndromes [J]. Circulation, 2006(8):774.
    Bhatt D L, Seheiman J, Abraham N S. ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrontestinal risks of ntiplatelet therapy and NSAID use:a report of the American College of Cardiology Foundation Task Forceon Clinical ExPert Consensus Doeument [J]. Circulation, 2008, (18):1894.
    Ali T, Harry R F. Stress-induced ulcer bleeding in critically ill patients [J]. Gastroenterology Clinics of North America, 2009(2):245.
    Sung J J, Barkun A, Kuipers E J. Intravenous esomeprazole for prevention of Recurrent peptic ulcer bleeding:a randomized trial [J]. Annals of Internal Medicine, 2009(7):455.
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  • 发布日期:  2013-02-27

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