受磷蛋白磷酸化位点Ser16在大鼠心力衰竭中的作用及机制

陈开祥; 周新华; 秦爱建

受磷蛋白磷酸化位点Ser16在大鼠心力衰竭中的作用及机制

1.
江苏省连云港市第二人民医院急诊中心,江苏连云港,222000;
2.
扬州大学江苏省动物预防医学重点实验室,江苏扬州,225003

基金项目: 连云港市卫生局科研项目

详细信息

中图分类号: R542.2
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出版历程
- 发布日期: 2013-02-27

摘要

摘要: 心力衰竭是各种心脏疾病的终末阶段,研究心力衰竭的发生机制对该病的防治极其重要.心肌舒缩功能与肌浆网钙泵(SERCA2a)的活性密切相关,SERCA2a活性主要由受磷蛋白(PLB)调控,PLB是心脏心肌收缩和β-肾上腺素能激活的基本调节蛋白[1].本实验通过建立异丙肾上腺素诱导心力衰竭大鼠模型,观察心力衰竭大鼠肌浆网PLB基因和蛋白表达与磷酸化的变化.
- 心力衰竭 /
- 受磷蛋白 /
- 大鼠H-89

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参考文献(10)

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