超声微泡造影剂经导管直接溶栓治疗犬股静脉血栓的实验研究

苏畅; 王芳芳; 段续微; 周玉斌

超声微泡造影剂经导管直接溶栓治疗犬股静脉血栓的实验研究

1.
辽宁省人民医院超声诊断科,辽宁沈阳,110016;
2.
辽宁省人民医院体检中心,辽宁沈阳,110016;
3.
辽宁省人民医院血管外科,辽宁沈阳,110016

详细信息

中图分类号: R814.43
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出版历程
- 发布日期: 2013-02-27

Research of ultrasound combined with microbubble contrast agent by catheter-directed thrombolysis on treatment for femoral vein thrombus of dogs

摘要

摘要: 目的研究超声联合微泡造影剂在体内的溶栓效应,并探讨其与尿激酶的协同作用.方法 13只健康犬建立血栓模型,分为对照组,尿激酶组,尿激酶加超声和微泡组,给予相应的治疗,应用超声多普勒,X线血管造影对血管的再通率进行评价,并进行病理学检查,比较各组溶栓效果.结果治疗后血管再通率尿激酶组与尿激酶加超声及微泡组均为100％,尿激酶加超声及微泡组再通等级优于尿激酶组.对照组血管再通率为0％,差异有统计学意义.光镜下观察,对照组股静脉管腔完全梗阻,血管壁见附壁血栓.尿激酶组、尿激酶加超声及微泡组股静脉管腔内部部分融通,局部区域内皮细胞脱落.结论超声联合微泡造影剂有一定的溶栓效应,与尿激酶共同应用,可以起协同作用.
- 超声 /
- 微泡造影剂 /
- 犬 /
- 股静脉 /
- 血栓 /
- 彩色多普勒 /
- 数字减影血管造影

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参考文献(15)

Mayer S, Grayburn PA. Myocardial contrast agents:recent advances and future directions [J]. Progress in Cardiovascular Diseases, 2002(1):33.

Lawrie A, Brisken A F, Francis S E. Microbubble enhanced ultrasound for vascular delivery [J]. Gene Therapy, 2000.2023.

Culp W C, Erdem E, Roberson P K. Microbubble potentiated ultrasound as a method of stroke therapy in a pig model:preliminary findings [J]. Journal of Vascular and Interventional Radiology, 2003, (11):1433.

钟南山. 深静脉血栓及肺小动脉血栓栓塞症早期诊断的新技术评介 [J]. 中国实用内科杂志, 2012, (11):817.

阮长耿. 血栓出凝血疾病研究现状及展望 [J]. 中国实用内科杂志, 2011(3):161.

华兴, 刘平, 李馨. 脂质体微泡促进超声波溶栓作用的体外实验 [J]. 中国医学影像技术, 2008(3):319.doi: 10.3321/j.issn:1003-3289.2008.03.001.

Unger E C, Matsunaga T O, McCzeery TP. Therapeutic applications of microbubbles [J]. European Journal of Radiology, 2002(2):160.

Schumann P A, Christiansen J P, Quigley R M. Targeted-microbubble bingding selectively to GP Ⅱ b Ⅲ a receptors of platelet thrombi [J]. Investigative Radiology, 2002, (11):587.

Janssen AP, Schiffelers RM, Ten Hagen TL. Peptidetargeted PEG-liposomes in anti-angiogenic therapy [J]. International Journal of Pharmaceutics, 2003(1):55.

Nedelmann M, Eicke BM, Nolle F. The ultrasound contrast medium Levovist increases the thrombolytic effect of low frequency ultrasound [J]. Medizinische Klinik, 2002.216.

Xie F, Tsutstti J M, Lof. Effectiveness of lipid microbubbles and ultrasound in declotting thrombolysis [J]. Ultrasound in Medicine and Biology, 2005.979.

Hwang J H, Brayman A A, Reidy M A. Vascular effects induced by combined 1-MHz ultrasound and microbubble contrast agent treatments in vivo [J]. Ultrasound in Medicine and Biology, 2005(4):553.

Devcic-Kuhar B, Pfaffenberger S, Groschl M. In vitro thrombolysis enhanced by standing and travelling ultrasound wave field [J]. Ultrasound in Medicine and Biology, 2002.1181.

Siegel R J, Atar S, Fishbein M C. Noninvasive transcutaneous low frequency ultrasound enhances thrombolysis in peripheral and coronary arteries [J]. Echocardiography, 2001.247.

徐亚丽, 高云华, 刘政. 微泡增强超声助溶兔股动脉血栓的实验研究 [J]. 中国超声医学杂志, 2006(6):404.doi: 10.3969/j.issn.1002-0101.2006.06.002.