Contrasting analysis on effect of cetylpyridinium chloride and povidone iodine on oral candidiasis
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摘要: 目的 对比西吡氯铵与聚维酮碘含漱液对口腔念珠菌感染的疗效及安全性.方法 将83例口腔念珠菌感染患者随机分为2组,治疗组(n=42)给予西吡氯铵含漱液,对照组(n=41)给予聚维酮碘含漱液.比较2组患者口腔疼痛、黏膜萎缩、红斑评分,菌落数、镜检阳性率、综合疗效及不良反应的差异.结果 2组患者各症状评分均较治疗前显著改善,但治疗组改善幅度大于对照组；2组治疗后菌落数及真菌镜检阳性率均较治疗前显著下降,但2组之间无显著差异；治疗组显效率显著高于对照组,而2组总有效率之间无显著差异.治疗组未发生明显不适反应,对照组发生1例口腔黏膜充血.结论 与聚维碘酮相比较,西吡氯铵含漱液对口腔念珠菌感染患者口腔疼痛、黏膜萎缩、红斑等症状的缓解作用更强,清除真菌的作用也有一定程度的提高,且安全性高,使用方便,具有临床推广价值.
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