Comparative analysis of efficacy of sequential therapy, quadruple therapy and standard triple therapy for the eradication of helicobacter pylori
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摘要: 目的 对比序贯疗法、四联疗法及标准三联疗法根除幽门螺杆菌(Hp)的疗效.方法 选取本院门诊Hp阳性病例105例,随机分为3组,A组采用序贯疗法；B组采用四联疗法；C组采用标准三联疗法.停药4周后复查胃镜、快速尿素酶试验及14C呼气试验,观察慢性胃炎改善、溃疡愈合及Hp根除情况.结果 四联疗法与序贯疗法,对Hp阳性的慢性胃炎及消化性溃疡患者的Hp根除率、慢性胃炎改善及溃疡愈合,以及Hp感染复发率方面均显示出良好的疗效,而标准三联疗法显著劣于其他2种方案.3种方案的不良反应发率均较低,且程度轻.结论 含泌剂四联疗法与序贯疗法在根除Hp、改善慢性胃炎、促进溃疡愈合以及降低复发率的疗效优于标准三联疗法,且不增加不良反应发生率及程度,可作为Hp感染初治患者的首选方案.
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宋慧东, 舒建昌, 杨绮红. 雷贝拉唑四联疗法根除幽门螺杆菌感染疗效观察 [J]. 南方医科大学学报, 2009(7):1501.doi: 10.3321/j.issn:1673-4254.2009.07.054. McClain M S, Shaffer C L, Israel D A. Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer [J]. BMC Genetics, 2009.3. 中国中西医结合学会消化系统疾病专业委员会. 慢性胃炎的中西医结合诊治方案 [J]. 现代消化及介入诊疗, 2005(3):181.doi: 10.3969/j.issn.1672-2159.2005.03.030. Hussain M A, Naveed S A, Sechi L A. Isocitrate Dehydrogenase of Helicobacter pylori Potentially Induces Humoral Immune Response in Subjects with Peptic Ulcer Disease and Gastritis [J]. PLoS ONE, 2008(1):e1481. 成虹, 胡伏莲, 谢勇. 中国幽门螺杆菌耐药状况及耐药对治疗的影响一全国多中心临床研究 [J]. 胃肠病学, 2007(9):525. Dehghani S M, Erjaee A, Imanieh M H. Efficacy of the standard quadruple therapy versus triple therapies containing proton pump inhibitor plus amoxicillin and clarithromycin or amoxicillin-clavulanic acid and metronidazole for Helicobacter pylori eradication in children [J]. Digestive Diseases and Sciences, 2009(8):1720. Gatta L, Vakil N, Leandro G. Sequential therapy or triple therapy for Helicobacter pylori infection:systematic review and meta-analysis of randomized controlled trials in adults and children [J]. American Journal of Gastroenterology, 2009, (12):3069. Sanchez-Delgado J, Calvet X, Bujanda L. Ten-day sequential treatment for Helicobacter pylori eradication in clinical practice [J]. American Journal of Gastroenterology, 2008(9):2220.
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