Clinical research of negative anti-reflux technique combined with interleukin-2 for malignant pleural effusion
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摘要: 目的 观察负压防反流技术联合白介素-2(IL-2)治疗恶性胸腔积液临床疗效及安全性.方法 196例恶性胸腔积液患者随机分为3组:A组应用负压防反流装置,将胸腔积液引流干净注入IL-2;B组应用胸腔置中心静脉导管引流胸水,无胸水流出时注入IL-2;C组应用胸腔穿刺抽液,至不能抽出胸水时注入IL-2.比较3组患者临床疗效及安全性.结果 A组136例患者胸水治疗总有效率明显高于B、C组；而1年、2年、3年无胸水生存率明显高于B、C组；所有患者耐受良好,无严重毒副反应及并发症.结论 负压反流技术联合IL-2治疗恶性胸腔积液有效率及安全性高,值得临床普遍推广应用.
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