Clinical significance of detecting VEGF in exhaled breath condensate of patients with lung cancer
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摘要: 目的 测定非小细胞肺癌患者(NSCLC)呼出气冷凝液(EBC)中血管内皮生长因子(VEGF)并研究其临床意义.方法 收集40例经病理确诊的NSCLC患者、20例稳定期的慢性阻塞性肺疾病(COPD)患者和20例健康体检者的EBC和血清标本,采用酶联免疫吸附法(ELISA)分别检测EBC和血清中VEGF水平.结果 ①NSCLC组EBC和血清中VEGF水平[(11.7±6.1) pg/mL、(310.5±23.9) pg/mL]显著高于COPD组[(6.3±4.9) pg/mL、(217.1±14.7) pg/mL]及正常对照组[(3 6±1.2) pg/mL、(162.5±16.5) pg/mL].②EBC和血清中VEGF水平与NSCLC患者的TNM分期及淋巴结转移呈正相关,与肺癌病理类型及患者性别、年龄、吸烟史无密切关系.结论 检测EBC中VEGF有助于肺癌的早期诊断、病情进展及预后判断.
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Chang S, Dai M, Ren JS. Estimates and prediction on incidence, mortality and prevalence of lung cancer in China in 2008 [J]. Zhonghua Liuxingbingxue Zazhi, 2012(4):391. Koutsokera A, Loukides S, Gourgoulianis K I. Biomarkers in the exhaled breath condensate of healthy adults:mapping the path towards reference values [J]. Current Medicinal Chemistry, 2008(6):620. Chan H P, Lewis C, Thomas P S. Exhaled breath analysis:novel approach for early detection of lung cancer [J]. Lung Cancer, 2009(2):164. Folkman J. Is angiogenesis an organizing principle in biology and medicine [J]. Journal of Pediatric Surgery, 2007(1):1. Ho Q T, Kuo C J. Vascular endothelial growth factor:biology and therapeutic applications [J]. International Journal of Biochemistry & Cell Biology, 2007, (7-8):1349. Kabashima A, Maehara Y, Kakeji Y. Overexpression of vascular endothelial growth factor C is related to lymphogenous metastasis in early gastric carcinoma [J]. Oncology(Basel), 2001(2):146. Jin Y, Li J P, Tang L Y. Protein expression and significanceof VEGF, EGFR and MMP-9 in non-small cell bung carcinomas [J]. Asian Pacific Journal of Cancer Prevention, 2011(6):1473. Dalaveris E, Kerenidi T, Katsabeki-Katsafli A. VEGF, TNF-alpha and 8-isoprostane levels in exhaled breath conden sate and sernrn of patients with lung cancer [J]. Lung Cancer, 2009(2):219. Gessner C, Rechner B, Hammerschmidt S. Angiogenic markers in breath condensate identify non-small cell lung canccr [J]. Lung Cancer, 2010(2):177.
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