Randomized controlled study on efficacy and safety of domestic palonosetron hydrochloride in prevention of nausea and vomiting induced by chemotherapy
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摘要: 目的 评价盐酸帕洛诺司琼预防高度催吐危险的化疗方案所致恶心、呕吐的疗效和安全性.方法 将符合纳入标准的恶性肿瘤患者随机分入AB组和BA组,于化疗前30 min缓慢静推盐酸帕洛诺可琼或盐酸托烷司琼.观察化疗后5d内恶心、呕吐情况,以及不良反应.结果 共纳入24例患者,可评价18例.2种药物对恶心、急性呕吐的完全控制率及有效控制率,以及对迟发性呕吐的完全控制率比较,无显著差异,而盐酸帕洛诺司琼对迟发性呕吐的有效控制率显著高于盐酸托烷司琼.2种药物不良反应较少且程度较轻.结论 盐酸帕洛诺司琼预防高度催吐危险的化疗方案所致恶心和急性呕吐的疗效与盐酸托烷司琼相当,但预防迟发性呕吐的疗效优于盐酸托烷司琼,且不良反应发生率低、程度轻.
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