基因OCT4、CD133在非小细胞肺癌组织中的表达及临床意义

倪静怡, 杨磊, 朱兴华, 茅国新

倪静怡, 杨磊, 朱兴华, 茅国新. 基因OCT4、CD133在非小细胞肺癌组织中的表达及临床意义[J]. 实用临床医药杂志, 2012, (19): 19-22.
引用本文: 倪静怡, 杨磊, 朱兴华, 茅国新. 基因OCT4、CD133在非小细胞肺癌组织中的表达及临床意义[J]. 实用临床医药杂志, 2012, (19): 19-22.
NI Jingyi, YANG Lei, ZHU Xinghua, MAO Guoxin. Expression and significance of OCT4 , CD133 in non-small cell lung cancer[J]. Journal of Clinical Medicine in Practice, 2012, (19): 19-22.
Citation: NI Jingyi, YANG Lei, ZHU Xinghua, MAO Guoxin. Expression and significance of OCT4 , CD133 in non-small cell lung cancer[J]. Journal of Clinical Medicine in Practice, 2012, (19): 19-22.

基因OCT4、CD133在非小细胞肺癌组织中的表达及临床意义

基金项目: 中国高校医学期刊临床专项资金
详细信息
  • 中图分类号: R734.2

Expression and significance of OCT4 , CD133 in non-small cell lung cancer

  • 摘要: 目的 比较OCT4、CD133在非小细胞肺癌(NSCLC)组织、癌旁组织及正常肺组织中的表达水平,并探讨2者与临床特征之间的关系.方法 随机选取NSCLC癌组织50例、癌旁组织及正常肺组织各20例,采用免疫组化法检测OCT4和CD133的表达情况,分析2者与NSCLC患者临床病理特征的关系.结果 癌旁组织及正常肺组织OCT4、CD133蛋白的表达率均显著低于NSCLC癌组织.OCT4在低分化及未分化癌组织中的表达率高于高、中分化组织,OCT4和CD133在有远处转移的NSCLC癌组织中的表达率高于无远处转移组织.50例NSCLC癌组织中,OCT4与CD133共同阳性15例,共同阴性12例,2者之间有明显相关性(P =0.0218).结论 OCT4和CD133在正常细胞向恶性细胞转化的过程中可能扮演了重要角色,检测OCT4和CD133的表达可能有助于对肺癌的早期诊断,为肿瘤干细胞标记物的确定、分化以及对肿瘤干细胞的靶向治疗提供理论依据.
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出版历程
  • 发布日期:  2013-01-15

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