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摘要: 丙型肝炎病毒(HCV)感染是一种常见的引起肝脏疾病的重要原因.清除干扰素的主要机制是经肾脏代谢,对以干扰素为基础治疗的终末期肾病患者来讲,合适的干扰素剂量选择很重要.单剂量药代动力学研究表明,肾功能不全患者肾清除的聚乙二醇干扰素α-2b (PEG IFN α 2b)药物的总清除率仅30％的[1],表明可能存在其他更占优势的药物清除路线存在.通过肾脏清除药物的比例较低,可能原因是大的PEG-干扰素分子不易透过.
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