Clinical efficacy and safety of rabeprazole combined with mosapride in the treatment of reflux esophagitis
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摘要: 目的 探讨雷贝拉唑联合莫沙必利治疗反流性食管炎(RE)的临床疗效及安全性.方法 将90例RE患者随机分为2组,观察组予雷贝拉唑联合莫沙必利,对照组给予奥美拉唑联合莫沙必利.比较2组症状评分的变化、临床症状和胃镜下征象的总体疗效,以及不良反应.结果 治疗4周、8周时症状评分均较治疗前显著下降;治疗4周时,观察组各症状评分下降程度大于对照组,治疗8周时,观察组胸骨后烧灼痛的症状评分显著低于对照组.观察组临床症状治愈率显著高于对照组,观察组胃镜下征象的治愈率及总有效率均高于对照组,2组不良反应发生率无显著差异,且均可耐受.结论 雷贝拉唑联合莫沙必利对RE的临床症状及胃镜下征象的改善作用较好,且安全性高,可作为反流性食管炎的首选治疗方案.
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