IL-16基因-295 T＞C多态性与肾透明细胞癌易感性的相关性研究

杜拥军; 殷长军; 朱建; 居小兵; 孟小鑫; 秦超; 王美林; 张正东; 张炜

IL-16基因-295 T＞C多态性与肾透明细胞癌易感性的相关性研究

1.
江苏省苏北人民医院泌尿外科,江苏扬州,225001;
2.
南京医科大学第一附属医院泌尿外科,江苏南京,210029;
3.
南京医科大学公共卫生学院分子遗传毒理实验室,江苏南京,210029

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中图分类号: R737.11
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- 发布日期: 2013-01-15

Correlation between IL-16 gene-295 T＞C polymorphism and risk of renal cell carcinoma

摘要

摘要: 目的研究中国南方汉族人群中白细胞介素-16(IL-16)基因-295 T＞C多态性与肾透明细胞癌(CCRCC)易感性的相关性.方法采用以医院为基础的病例对照研究模式,通过面访填写调查表并采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测年龄和性别匹配的中国南方汉族300例患者和300例正常人群的IL-16 gene-295T＞C基因型.并采用分层分析进一步探讨与罹患CCRCC相关的可能因素.结果与TT型携带者相比,CT型(OR=0.78,95％CI=0.55～1.09)或CC型(0.37,0.19～0.73)携带者发生CCRCC的危险性明显降低.分层分析显示年龄、体重指数及饮酒与CCRCC危险性之间无明显关联,携带CT或CC型从不吸烟的女性患者发生CCRCC的危险性明显降低(从不吸烟:0.61,0.41～0.91;女性:0.52,0.30～0.91).结论 IL-16 gene-295T＞C多态性可能与我国南方地区汉族人群CCRCC易感性有关,CC型或CT型携带者发生CCRCC的危险性要明显低于TT型携带者.
- 肾透明细胞癌 /
- 白细胞介素-16 /
- 单核苷酸多态性 /
- 遗传易感性

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文章访问数: 113
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IL-16基因-295 T＞C多态性与肾透明细胞癌易感性的相关性研究

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出版历程

Correlation between IL-16 gene-295 T＞C polymorphism and risk of renal cell carcinoma

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