Periostin基因多态性与苏皖汉族人群冠心病发病的初步研究

周学军, 纪元, 蒋建光, 刘志平, 王芳芳, 丁志坚

周学军, 纪元, 蒋建光, 刘志平, 王芳芳, 丁志坚. Periostin基因多态性与苏皖汉族人群冠心病发病的初步研究[J]. 实用临床医药杂志, 2012, (17): 15-17,24.
引用本文: 周学军, 纪元, 蒋建光, 刘志平, 王芳芳, 丁志坚. Periostin基因多态性与苏皖汉族人群冠心病发病的初步研究[J]. 实用临床医药杂志, 2012, (17): 15-17,24.
ZHOU Xue-jun, JI Yuan, JIANG Jian-guang, LIU Zhi-ping, WANG Fang-fang, DING Zhi-jian. Preliminary research on Periostin gene polymorphisms and incidence of coronary artery disease in Han nationality of Jiangsu and Anhui provinces[J]. Journal of Clinical Medicine in Practice, 2012, (17): 15-17,24.
Citation: ZHOU Xue-jun, JI Yuan, JIANG Jian-guang, LIU Zhi-ping, WANG Fang-fang, DING Zhi-jian. Preliminary research on Periostin gene polymorphisms and incidence of coronary artery disease in Han nationality of Jiangsu and Anhui provinces[J]. Journal of Clinical Medicine in Practice, 2012, (17): 15-17,24.

Periostin基因多态性与苏皖汉族人群冠心病发病的初步研究

详细信息
  • 中图分类号: R541.4

Preliminary research on Periostin gene polymorphisms and incidence of coronary artery disease in Han nationality of Jiangsu and Anhui provinces

  • 摘要: 目的 研究Periostin(POSTN)基因多态性与苏皖汉族人群冠心病发病的关系.方法 采用聚合酶链反应-限制性片段长度多态法检测POSTN基因启动子区位点(SNP A-953T)基因型.观察POSTN基因突变率与冠心病发病的可能关系.结果 证实在中国人群POSTN A-953T存在TT基因型.冠心病患者基因型分布:POSTN A-953T(AA型275例,AT型202例,TT型16例).正常人群基因型分布:POSTN A-953T(AA型368例,AT型266例,TT型31例).POSTN基因型分布冠心病组与正常人群间差异无显著性意义.结论 POSTN基因多态性与冠心病发病危险未发现明显相关.
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出版历程
  • 发布日期:  2013-01-15

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