Clinical study of intermediate coronary stenosis patients with impaired glucose tolerance by using intravascular ultrasound
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摘要: 目的 对于冠脉造影提示临界病变的患者,通过血管内超声检查,了解冠心病合并糖耐量减低的冠脉病变斑块情况,探讨糖耐量减低对冠状动脉病变的影响.方法 89例临床诊断为冠心病的患者,分为合并2型糖尿病(T2DM)组(A组)、糖耐量减低(IGT)组(B组)、糖代谢正常组(NDM)(C组),所有患者均进行冠状动脉造影检查,明确至少有一支主要冠状动脉狭窄程度在40％～70％,所有患者均行血管内超声检查,测量临界病变处血管外弹力膜面积(EEMA)、斑块面积(PA)、最小管腔面积(MLA)、斑块负荷(PB),并分析斑块性质.结果 A组与B组合并高血压及高血脂的发生率较C组高,A组与B组间无显著差别;A组与B组MLA明显＜C组,而EEM、PA和PB明显＞C组.A组与B组软斑块及血栓形成病例均较C组多见.结论 在冠脉造影提示临界冠脉病变的冠心病患者中,合并糖耐量减低患者与合并糖尿病患者一样,冠脉病变均较严重,且斑块不稳定,故对合并糖耐量减低的冠心病患者应及早干预,积极控制血糖.
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