血清环氧化酶-2和白介素-6水平在婴儿肺炎中的意义及相关性探讨

血清环氧化酶-2和白介素-6水平在婴儿肺炎中的意义及相关性探讨[J]. 实用临床医药杂志, 2009, (17): 48-50.
引用本文: 血清环氧化酶-2和白介素-6水平在婴儿肺炎中的意义及相关性探讨[J]. 实用临床医药杂志, 2009, (17): 48-50.
Significance of and correlation between the levels of serum COX-2 and IL-6 in infant pheumonia[J]. Journal of Clinical Medicine in Practice, 2009, (17): 48-50.
Citation: Significance of and correlation between the levels of serum COX-2 and IL-6 in infant pheumonia[J]. Journal of Clinical Medicine in Practice, 2009, (17): 48-50.

血清环氧化酶-2和白介素-6水平在婴儿肺炎中的意义及相关性探讨

详细信息
  • 中图分类号: R725.6

Significance of and correlation between the levels of serum COX-2 and IL-6 in infant pheumonia

  • 摘要: 目的 探讨婴儿肺炎患者血清环氧化酶-2(COX-2)、白细胞介素-6(IL-6)的变化及临床意义.方法 选择2007年10月~2008年5月在常州市第二人民医院住院治疗的婴儿肺炎急性期患者56例,其中男36例,女20例;年龄2~12月,纳入病例组;同期在上述医院进行体检的32例健康儿童作为对照组,差异无显著意义.采用酶联免疫吸附法((ELISA)检测治疗前和治疗后7天病例组和健康对照组血清标本中COX-2、IL-6的浓度并进行统计学分析.结果 病例组治疗前血清COX-2(48.26±19.92) IU/L、IL-6(65.23±23.52) pg/mL较对照组COX-2(33.87±15.22) IU/L、IL-6(16.04±11.41) pg/mL明显升高;两者均有显著性差异(P<0.001).病例组治疗7天后血清COX-2、IL-6水平与对照组相比无显著性差异(P>0.05).血清COX-2与IL-6水平变化有统计学正相关性(P<0.001).结论 COX-2、IL-6可能参与了婴儿肺炎的发病过程,动态检测它们的含量,对于评估肺部感染是否被控制有一定的临床意义.
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  • 发布日期:  2009-11-29

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