大剂量阿托伐他汀对大鼠主动脉平滑肌细胞基质金属蛋白酶-2的影响

大剂量阿托伐他汀对大鼠主动脉平滑肌细胞基质金属蛋白酶-2的影响[J]. 实用临床医药杂志, 2009, (17): 24-26.
引用本文: 大剂量阿托伐他汀对大鼠主动脉平滑肌细胞基质金属蛋白酶-2的影响[J]. 实用临床医药杂志, 2009, (17): 24-26.
Effects of high doses of atorvastatin on the expression of matrix metalloproteinase-2 of rat vascular smooth muscle cells[J]. Journal of Clinical Medicine in Practice, 2009, (17): 24-26.
Citation: Effects of high doses of atorvastatin on the expression of matrix metalloproteinase-2 of rat vascular smooth muscle cells[J]. Journal of Clinical Medicine in Practice, 2009, (17): 24-26.

大剂量阿托伐他汀对大鼠主动脉平滑肌细胞基质金属蛋白酶-2的影响

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  • 中图分类号: R541.4

Effects of high doses of atorvastatin on the expression of matrix metalloproteinase-2 of rat vascular smooth muscle cells

  • 摘要: 目的 研究不同剂量阿托伐他汀对培养的大鼠主动脉血管平滑肌细胞(VSMC)基质金属蛋白酶-2(MMP-2)活性的影响.方法 用含10%小牛血清的DMEM培养液体外培养大鼠主动脉VSMC, 随机分为对照组,不同剂量阿托伐他汀干预组,运用MMP-2活性酶图分析法结合光密度扫描分析,观察不同剂量阿托伐他汀对VSMC的MMP-2表达的影响.结果 不同剂量阿托伐他汀组均明显抑制MMP-2的活性,且具有剂量依赖性.结论 阿托伐他汀可以显著降低VSMC的MMP-2的表达,大剂量抑制作用更强.
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出版历程
  • 发布日期:  2009-11-29

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