系统性红斑狼疮患者骨髓间质干细胞对T细胞增殖作用的研究
详细信息-
摘要: 骨髓间充质干细胞(MSCs) 是存在于骨髓微环境中的多潜能非造血干细胞,具有调节造血干细胞的生长和分化的功能.体外MSCs具有高度扩增、多向分化和自我更新的能力.近年,MSCs的免疫调节作用备受关注, MSCs可抑制T细胞的活化和增殖、促进造血、防治移植物抗宿主病(GVHD)等, MSCs与同种异体T淋巴细胞共培养时不能引起T细胞的增殖反应.由于它的无或低免疫原性和免疫调节作用,MSCs移植在临床上有广阔的应用前景.
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