头孢曲松钠联合苄星青霉素治疗二期梅毒的效果观察

吉竹云

doi:10.7619/jcmp.202024027

头孢曲松钠联合苄星青霉素治疗二期梅毒的效果观察

吉竹云

陕西省延安市富县人民医院皮肤科, 陕西延安, 727500

基金项目:

陕西省社会发展科技攻关项目(2016SF-257)

详细信息

中图分类号: R759.1;R969
计量
- 文章访问数: 513
- HTML全文浏览量: 49
- PDF下载量: 17
出版历程
- 收稿日期: 2020-10-07
- 网络出版日期: 2020-12-29

Effect observation of ceftriaxone sodium combined with benzathine penicillin in the treatment of patients with secondary syphilis

JI Zhuyun

Department of Dermatology, Fuxian People's Hospital in Yan'an City of Shaanxi Province, Yan'an, Shaanxi, 727500

摘要

摘要: 目的观察头孢曲松钠联合苄星青霉素治疗二期梅毒的效果。方法选取本院收治的二期梅毒患者80例,随机分为对照组和研究组。对照组采用苄星青霉素治疗,研究组采用头孢曲松钠联合苄星青霉素治疗,比较2组治疗效果。结果研究组总有效率为97.50%, 高于对照组的75.00%, 差异有统计学意义(P<0.05)。研究组治疗后30、60、90 d的梅毒血清试验(TRUST)转阴率均高于对照组,差异有统计学意义(P<0.05)。研究组皮损症状消退时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,研究组CD3⁺、CD4⁺、CD8⁺、CD4⁺/CD8⁺等外周血T淋巴细胞亚群指标水平改善情况优于对照组,差异有统计学意义(P<0.05)。结论头孢曲松钠联合苄星青霉素治疗二期梅毒的效果显著,可提高临床疗效,促进皮损症状消退。
- 头孢曲松钠 /
- 苄星青霉素 /
- 二期梅毒 /
- 皮损症状 /
- T淋巴细胞
Abstract: Objective To observe the effect of ceftriaxone sodium combined with benzathine penicillin in the treatment of patients with secondary syphilis. Methods Eighty patients with secondary syphilis admitted in our hospital were selected and randomly divided into control group and study group. The control group was treated with benzathine penicillin, and the study group was treated with ceftriaxone sodium and benzathine penicillin. The efficacy was compared between the two groups. Results The total effective rate of the study group was 97.50%, which was significantly higher than 75.00% of the control group(P<0.05). The negative conversion rates of toluidine red unheated serum test(TRUST)in the study group were significantly higher than those in the control group at 30, 60 and 90 days after treatment(P<0.05). The remission time of skin lesions in the study group was significantly shorter than that in the control group(P<0.05). After treatment, the improvement of peripheral blood T lymphocyte subsets such as CD3⁺, CD4⁺, CD8⁺ and CD4⁺/CD8⁺ in the study group was significantly better than that in the control group(P<0.05). Conclusion Ceftriaxone sodium combined with benzathine penicillin is effective in the treatment of patients with secondary syphilis, which can increase the clinical efficacy and promote the regression of skin lesions.
- ceftriaxone sodium /
- benzathine penicillin /
- secondary syphilis /
- skin lesions /
- T lymphocytes

HTML全文

参考文献(14)

林斌, 林雁嘉, 黄楚韩, 等. 头孢曲松钠与苄星青霉素治疗二期梅毒疗效对比[J]. 皮肤病与性病, 2020, 42(2): 201-202.

赵蕾. 苄星青霉素、头孢曲松钠单药及联合治疗梅毒患者的效果比较[J]. 中国民康医学, 2020, 32(8): 27-29.

赵艳霞, 贾婷婷, 王鹏雨, 等. 以阴囊环状红斑为主要表现的复发性二期梅毒1例[J]. 中国皮肤性病学杂志, 2020, 34(7): 849-850.

尹雪锋, 丁克云. 苄星青霉素联合头孢曲松治疗对早期梅毒患者RPR阴转率、血清固定率的影响研究[J]. 皮肤病与性病, 2020, 42(1): 41-42.

颜霞. 血浆反应素环状卡片试验与梅毒螺旋体明胶颗粒凝集试验在梅毒抗体临床检测中应用效果的比较研究[J]. 临床合理用药杂志, 2019, 12(36): 158-160.

刘春慧, 王凯波. 长效西林联合头孢曲松对二期梅毒症状的临床疗效及安全性评价[J]. 中国性科学, 2019, 28(12): 114-117.

王耀武, 王建军, 武丽. 隐性梅毒感染采用苄星青霉素联合头孢曲松钠的疗效分析[J]. 宁夏医学杂志, 2019, 41(12): 1149-1151.

闫宁, 陈斌, 于晓云, 等. 头孢曲松钠联合苄星青霉素对各期不同滴度梅毒患者血清学转归的影响[J]. 中国性科学, 2019, 28(11): 133-136.

叶文峰. 苄星青霉素与头孢曲松联用对老年隐性梅毒感染的疗效及其对T细胞功能的影响[J]. 抗感染药学, 2019, 16(6): 943-946.

蔡正菊. 头孢曲松钠与苄星青霉素治疗二期梅毒的疗效[J]. 中国卫生标准管理, 2019, 10(10): 35-37.

贺迎霞, 张庆田, 王冬梅, 等. 胸腺五肽联合苄星青霉素对早期梅毒血清固定患者外周血T淋巴细胞亚群及血清TRUST转阴率的影响[J]. 中国性科学, 2018, 27(11): 115-118.

高英, 和义敏, 袁婧, 等. 早期梅毒患者外周血中氧化应激与免疫功能指标水平检测及意义[J]. 海南医学院学报, 2017, 23(22): 3150-3152

, 3156.

王春梅, 阮师漫, 徐力力, 等. 不同治疗方案在隐性梅毒感染患者合并皮肤病中的疗效研究[J]. 中华医院感染学杂志, 2017, 27(20): 4604-4606

, 4640.

艾镇临. 探讨头孢曲松钠联合苄星青霉素治疗潜伏梅毒患者其血清快速血浆反应素(RPR)的转归变化[J]. 世界最新医学信息文摘, 2017, 17(49): 101-103.

施引文献

资源附件(0)

计量

文章访问数: 513
HTML全文浏览量: 49
PDF下载量: 17
被引次数: 0

头孢曲松钠联合苄星青霉素治疗二期梅毒的效果观察

计量

出版历程

Effect observation of ceftriaxone sodium combined with benzathine penicillin in the treatment of patients with secondary syphilis

计量

出版历程

目录