Effect observation of ornidazole carboxymethyl chitosan combined with hyaluronic acid as an auxiliary means for periodontal initial therapy in treating elderly patients with chronic periodontitis
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摘要: 目的 观察奥硝唑羧甲基壳聚糖联合透明质酸辅助牙周基础治疗对老年慢性牙周炎的效果。 方法 选取慢性牙周炎老年患者112例,随机分为观察组和对照组,每组56例。所有患者均行牙周基础治疗,对照组术后从牙周袋底部将透明质酸注入,观察组将奥硝唑羧甲基壳聚糖联合透明质酸注入牙周袋底部。比较2组临床疗效,治疗前与治疗28 d后各项牙周指标,龈下菌斑胰蛋白酶样酶(TLE)的水平(OD值)和螺旋体占比(S%)。 结果 治疗28 d后, 2组附着丧失(AL)、出血指数(BI)、菌斑指数(PLI)、探针深度(PD)水平均低于治疗前,且观察组均低于对照组,差异有统计学意义(P<0.05)。治疗28 d后, 2组TLE、S%值均低于治疗前,且观察组均低于对照组,差异有统计学意义(P<0.05)。观察组总有效率为92.86%, 高于对照组的78.57%, 差异有统计学意义(P<0.05)。 结论 奥硝唑羧甲基壳聚糖联合透明质酸辅助牙周基础治疗对老年慢性牙周炎疗效显著,可改善牙周相关指标水平,降低TLE水平,减少龈下菌斑螺旋体数量。Abstract: Objective To observe the effect of ornidazole carboxymethyl chitosan combined with hyaluronic acid as an auxiliary means for periodontal initial therapy in treating elderly patients with chronic periodontitis. Methods Totally 112 elderly patients with chronic periodontitis were selected and randomly divided into observation group and controlgroup, with 56 cases in each group. All patients were treated with periodontal initial therapy, the control group was injected with hyaluronic acid from the bottom of periodontal bag after operation, and the observation group was injected with ornidazole carboxymethyl chitosan combined with hyaluronic acid into the bottom of periodontal bag. The clinical efficacy, periodontal indexes, the level of trypsin like enzyme(TLE)and the ratio of spirochetes(S%)were compared between the two groups before and after 28 days of treatment. Results After 28 days of treatment, the levels of attachment loss(AL), bleeding index(BI), plaque index(PLI)and probe depth(PD)in both groups were significantly lower than those before treatment, and those in the observation group were significantly lower than the control group(P<0.05). After 28 days of treatment, the values of TLE and S% in both groups were significantly lower than those before treatment, and those in the observation group were significantly lower than the control group(P<0.05). The total effective rate of the observation group was 92.86%, which was significantly higher than 78.57% of the control group(P<0.05). Conclusion Ornidazole carboxymethyl - chitosan combined with hyaluronic acid as an auxiliary means for periodontal initial therapy is effective in the treatment of elderly patients with chronic periodontitis, which can improve the level of periodontal related indicators, reduce the level of TLE and the number of spirochetes in subgingival plaque.
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