Effect of somatostatin combined with magnesium sulfate in treatment of severe acute pancreatitis
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摘要: 目的 探讨生长抑素联合硫酸镁治疗重症急性胰腺炎(SAP)患者的疗效及其对血清淀粉酶(AMS)、脂肪酶(LPS)和炎症因子水平的影响。 方法 将76例SAP患者随机分为对照组和观察组,每组38例。对照组采用生长抑素治疗,观察组采用生长抑素联合硫酸镁治疗。比较2组的治疗效果和并发症发生情况,并比较2组治疗前后的血清AMS、LPS水平和炎症因子水平。 结果 观察组治疗总有效率为94.74%, 高于对照组的78.95%, 差异有统计学意义(P<0.05); 治疗后,观察组血清LPS、AMS水平低于对照组,差异有统计学意义(P<0.05); 治疗后,观察组C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平低于对照组,差异有统计学意义(P<0.05); 观察组并发症发生率为5.26%, 低于对照组的21.05%, 差异有统计学意义(P<0.05)。 结论 生长抑素联合硫酸镁治疗SAP患者疗效确切,能够改善血清AMS、LPS水平,降低炎症因子水平,缓解胰腺损伤。Abstract: Objective To explore the efficacy of somatostatin combined with magnesium sulfate in the treatment of patients with severe acute pancreatitis(SAP)and its effects on the levels of serum amylase(AMS), serum lipase(LPS)and inflammatory factors. Methods A total of 76 SAP patients were randomly divided into control group(n=38, treated with somatostatin)and observation group(n=38, treated with somatostatin and magnesium sulfate). The therapeutic effect and complications were compared between the two groups, and the levels of serum AMS, LPS and inflammatory factors before and after treatment were compared between the two groups. Results The total effective rate in the observation group was 94.74%, which was significantly higher than 78.95% in the control group(P<0.05). The levels of LPS and AMS after treatment in the observation group were significantly lower than those in the control group(P<0.05). The C-reactive protein(CRP), tumor necrosis factor-α(TNF-α)and interlenkin-6(IL-6)levels after treatment in the observation group were significantly lower than those in the control group(P<0.05). The incidence of complications in the observation group was 5.26%, which was significantly lower than 21.05% in the control group(P<0.05). Conclusion Somatostatin combined with magnesium sulfate is effective in the treatment of SAP patients, which can improve the levels of serum AMS and LPS, reduce the levels of inflammatory factors, and alleviate pancreatic injury.
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Keywords:
- magnesium sulfate /
- somatostatin /
- severe acute pancreatitis /
- amylase /
- lipase /
- inflammatory factors
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