Value of serum anti-phospholipase A2 receptor antibody and renal function indicators in diagnosis of patients with idiopathic membranous nephropathy
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摘要: 目的 探讨血清抗人磷脂酶A2受体(PLA2R)抗体、肾功能指标对特发性膜性肾病的临床诊断价值。 方法 将100例特发性膜性肾病患者纳入A组,并选取同期住院的非特发性膜性肾病患者100例纳入B组,同期体检的健康人员100例纳入C组。比较A组不同病理分期患者的血清抗PLA2R抗体阳性率,比较3组受检者肾功能相关指标水平。 结果 A组半胱氨酸蛋白酶抑制剂C(Cys C)、血尿素氮(BUN)、肌酐(CREA)、尿酸(UA)、总蛋白(TP)、白蛋白(ALB)、24 h尿蛋白定量(24 h UP)水平与B组比较,差异无统计学意义(P>0.05); A组、B组Cys C、BUN、CREA、UA、24 h UP水平高于C组,TP、ALB水平低于C组,差异有统计学意义(P<0.05); 特发性膜性肾病患者中,Ⅰ期与Ⅱ期患者各肾功能指标水平比较,差异无统计学意义(P>0.05); Ⅲ期与Ⅳ期患者各肾功能指标水平比较,差异无统计学意义(P>0.05); Ⅲ期和Ⅳ期患者Cys C、BUN、CREA、UA、TP、ALB、24 h UP水平与Ⅰ期与Ⅱ期患者比较,差异有统计学意义(P<0.05); 特发性膜性肾病患者抗PLA2R抗体检测阳性率为68.0%,且抗PLA2R抗体阳性率与病理分期无相关性(P>0.05)。 结论 血清抗PLA2R抗体可作为特发性膜性肾病重要的血清学诊断指标,与肾功能指标联合检测有助于掌握患者病情进展情况。
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关键词:
- 特发性膜性肾病 /
- 抗人磷脂酶A2受体抗体 /
- 肾功能 /
- 半胱氨酸蛋白酶抑制剂C /
- 血尿素氮 /
- 肌酐 /
- 尿酸
Abstract: Objective To explore the clinical value of serum anti-phospholipase A2 receptor(PLA2R)antibody and renal function indicators in diagnosis of patients with idiopathic membranous nephropathy. Methods A total of 100 patients with idiopathic membranous nephropathy were included in group A, and 100 hospitalized non-idiopathic membranous nephropathy patients in the same period were selected as group B, and 100 healthy people with physical examination during the same period were selected as group C. The positive rates of serum anti-PLA2R antibody in the group A with differed staging were compared, and the indexes of renal function were analyzed between the three groups. Results The levels of cysteine C(Cys C), blood urea nitrogen(BUN), creatinine(CREA), uric acid(UA), total protein(TP), albumin(ALB), 24-hour urinary protein(24 h UP)in two groups showed no significant differences(P>0.05). Compared with group C, Cys C, BUN, CREA, UA, 24 h UP levels in groups A and B were significantly higher, and the levels of TP and ALB were significantly lower(P<0.05). The indicators of renal function in patients with different pathological idiopathic membranous nephropathy between stage Ⅰ and stage Ⅱ as well as between stage Ⅲ and stage Ⅳ showed no significant differences(P>0.05). Compared with patients in stages Ⅰ and Ⅱ, the levels of Cys C, BUN, CREA, UA, TP, ALB, 24 h UP in those with stage Ⅲ and stage Ⅳ showed significant differences(P<0.05). The positive rate of anti-PLA2R antibody detection in patients with idiopathic membranous nephropathy was 68.0%, which was not related to the pathological staging(P>0.05). Conclusion Serum anti-PLA2R antibody can be used as an important serological - indicator in diagnosing idiopathic membranous nephropathy, and joint detection with renal function indicators helps to grasp the progression of the disease. -
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