西洛他唑对颅内小动脉瘤患者支架介入术后血流动力学与再狭窄的影响

汪恒胜, 马海

汪恒胜, 马海. 西洛他唑对颅内小动脉瘤患者支架介入术后血流动力学与再狭窄的影响[J]. 实用临床医药杂志, 2020, 24(22): 14-16,20. DOI: 10.7619/jcmp.202022004
引用本文: 汪恒胜, 马海. 西洛他唑对颅内小动脉瘤患者支架介入术后血流动力学与再狭窄的影响[J]. 实用临床医药杂志, 2020, 24(22): 14-16,20. DOI: 10.7619/jcmp.202022004
WANG Hengsheng, MA Hai. Effect of cilostazol on hemodynamics and restenosis after stent implantation in patients with intracranial small aneurysm[J]. Journal of Clinical Medicine in Practice, 2020, 24(22): 14-16,20. DOI: 10.7619/jcmp.202022004
Citation: WANG Hengsheng, MA Hai. Effect of cilostazol on hemodynamics and restenosis after stent implantation in patients with intracranial small aneurysm[J]. Journal of Clinical Medicine in Practice, 2020, 24(22): 14-16,20. DOI: 10.7619/jcmp.202022004

西洛他唑对颅内小动脉瘤患者支架介入术后血流动力学与再狭窄的影响

详细信息
    通讯作者:

    马海, E-mail: mahai18578@126.com

  • 中图分类号: R743;R739.41

Effect of cilostazol on hemodynamics and restenosis after stent implantation in patients with intracranial small aneurysm

  • 摘要: 目的 探讨西洛他唑对颅内小动脉瘤患者支架介入术后血流动力学和再狭窄的影响。 方法 回顾性分析86例颅内小动脉瘤患者的临床资料,根据治疗时是否服用西洛他唑分为对照组和观察组,每组43例。2组均行支架介入术治疗,比较2组临床治疗效果、再狭窄率及预后情况,并比较2组麻醉前(T0)、麻醉诱导后2 min(T1)、插管后1 min(T2)、插管后3 min(T3)、插管后5 min(T4)的血流动力学变化。 结果 2组瘤腔栓塞效果比较,差异无统计学意义(P>0.05)。T0时点, 2组心率(HR)、收缩压(SBP)、舒张压(DBP)比较,差异无统计学意义(P>0.05); T1-T4时点,观察组HR均低于对照组,差异有统计学意义(P<0.05); 观察组血压较为平稳,且观察组T1时点的血压高于对照组, T2-T4时点的血压低于对照组,差异有统计学意义(P<0.05)。观察组再狭窄率为2.3%, 低于对照组的9.3%, 差异有统计学意义(P<0.05)。观察组预后良好率为81.4%, 高于对照组的65.1%, 差异有统计学意义(P<0.05)。 结论 西洛他唑应用于颅内小动脉瘤支架介入术患者可取得较好的临床治疗效果,有利于稳定血流动力学状态,且再狭窄率低,患者预后良好。
    Abstract: Objective To investigate the effect of cilostazol on hemodynamics and restenosis rate after stent implantation in patients with intracranial small aneurysm. Methods The clinical data of 86 patients with intracranial small aneurysms was retrospectively analyzed. According to whether administration of cilostazol or not during treatment, they were divided into control group and observation group, with 43 cases in each group. Both groups underwent stent implantation. Clinical treatment efficacy, restenosis rate and prognosis were compared, and changes of hemodynamic indicators before anesthesia(T0), 2 min after anesthesia induction(T1), 1 min after intubation(T2), 3 min after intubation(T3), and 5 min after intubation(T4)were compared. Results There was no significant difference in effect of tumor embolization between the two groups(P>0.05). There were no significant differences in heart rate(HR), systolic blood pressure(SBP)and diastolic blood pressure(DBP)at T0 between the two groups(P>0.05). The HR at time points from T1 to T4 of the observation group was significantly lower than that in the control group(P<0.05). The blood pressure of the observation group was stable, and their values were significantly lower at time points from T2 to T4 than those in the control group and blood pressure was significantly higher at T1 than that in the control group(P<0.05). The restenosis rate was 2.3% in the observation group, and was significantly lower than 9.3% in the control group(P<0.05). The good rate of the observation group was 81.4%, which was significantly higher than 65.1% in the control group(P<0.05). Conclusion Cilostazol in treating intracranial small aneurysm patients with stent implantation has better clinical effect, which is beneficial to stabilize the hemodynamic status, reduce the rate of restenosis, and obtain a favorable prognosis.
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  • 期刊类型引用(1)

    1. 宋承骏,毛茅,舒鹏飞,应乐园. 前列地尔联合西洛他唑治疗下肢动脉硬化闭塞症介入术后再狭窄的疗效. 中国药物与临床. 2024(20): 1346-1351 . 百度学术

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出版历程
  • 收稿日期:  2020-09-13
  • 网络出版日期:  2020-12-21
  • 发布日期:  2020-12-02

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