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哮喘对儿童骨发育的影响研究

徐聪聪, 林荣军, 金蓉, 管仁政, 曹悦花

徐聪聪, 林荣军, 金蓉, 管仁政, 曹悦花. 哮喘对儿童骨发育的影响研究[J]. 实用临床医药杂志, 2020, 24(19): 52-54. DOI: 10.7619/jcmp.202019015
引用本文: 徐聪聪, 林荣军, 金蓉, 管仁政, 曹悦花. 哮喘对儿童骨发育的影响研究[J]. 实用临床医药杂志, 2020, 24(19): 52-54. DOI: 10.7619/jcmp.202019015
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XU Congcong, LIN Rongjun, JIN Rong, GUAN Renzheng, CAO Yuehua. Study on effect of asthma on bone development in children[J]. Journal of Clinical Medicine in Practice, 2020, 24(19): 52-54. DOI: 10.7619/jcmp.202019015
Citation: XU Congcong, LIN Rongjun, JIN Rong, GUAN Renzheng, CAO Yuehua. Study on effect of asthma on bone development in children[J]. Journal of Clinical Medicine in Practice, 2020, 24(19): 52-54. DOI: 10.7619/jcmp.202019015
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哮喘对儿童骨发育的影响研究

  • 1. 青岛大学, 山东 青岛, 266000;

  • 2. 青岛大学附属医院, 山东 青岛, 266000;

  • 3. 山东省青岛同安妇婴医院, 山东 青岛, 266000;

  • 4. 山东省临沂市莒南县人民医院, 山东 临沂, 276600

基金项目: 

国家自然科学基金项目(81701587)

详细信息
    通讯作者:

    林荣军,E-mail:linrongjun0312@126.com

  • 中图分类号: R256.12

Study on effect of asthma on bone development in children

  • 1. Qingdao University, Qingdao, Shandong, 266000;

  • 2. Affiliated Hospital of QingdaoUniversity, Qingdao, Shandong, 266000;

  • 3. Qingdao Tongan Maternal and Child Hospital in Shandong Province, Qingdao, Shandong, 266000;

  • 4. Junan County People's Hospital of Linyi City in Shandong Province, Linyi, Shandong, 276600

摘要

    摘要
  • 摘要: 目的 探讨哮喘对儿童骨发育的影响。 方法 选取青岛大学附属医院小儿哮喘专科门诊确诊为轻中度支气管哮喘的80例患儿为研究对象,将其中40例轻度哮喘患儿纳入轻度哮喘组,另外40例中度支气管哮喘患儿纳入中度哮喘组,均接受吸入低剂量的糖皮质激素治疗,同时选取同期体检的30例健康患儿为对照组。检测3组患儿的骨密度(BMD)和血清1, 25-二羟维生素D3［1, 25-(OH)2D3］水平。 结果 轻度哮喘组和中度哮喘组BMD值低于对照组,差异有统计学意义(P<0.05); 中度哮喘组血清1, 25-(OH)2D3水平低于对照组,差异有统计学意义(P<0.05); 轻度哮喘组血清1, 25-(OH)2D3水平略低于对照组,但差异无统计学意义(P>0.05)。 结论 未经正规治疗的哮喘对儿童骨质发育有显著影响,且哮喘程度越严重影响越大。
    Abstract: Objective To investigate effect of asthma on bone development in children. Methods A total of 80 children with mild or moderate bronchial asthma diagnosed in pediatric asthma outpatient department of Affiliated Hospital of Qingdao University were selected as the research objects, among whom 40 children diagnosed as mild bronchial asthma children were selected as mild asthma group, another 40 moderate bronchial asthma were selected as moderate asthma group. These children were treated with low dose of glucocorticoid after diagnosis. At the same time, thirty healthy children with physical examinations were selected as control group. Bone mineral density(BMD)and serum 1, 25-dihydroxyvitamin D3［1, 25-(OH)2D3］ of three groups were measured. Results BMD values of mild asthma group and moderate asthma group were lower than those of the control group, and the difference was statistically significant(P<0.05). The serum 1, 25-(OH)2D3 level in the moderate asthma group was significantly lower than that in the control group(P<0.05). The serum 1, 25-(OH)2D3 level in the mild asthma group was slightly lower than that in the control group, but no difference was found(P>0.05). Conclusion Asthma without regular treatment can delay the bone development in children, the severer degree of asthma is, the more effect it will be.
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  • 收稿日期:  2020-07-25

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