Values of serum amyloid A and ratio of C reactive protein to prealbumin in diagnosis of acute exacerbation of chronic obstructive pulmonary disease complicated with lower respiratory tract infection
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摘要: 目的 分析血清淀粉样蛋白A(SAA)、C反应蛋白与前白蛋白比值(CRP/PA)早期诊断慢性阻塞性肺疾病急性加重期(AECOPD)合并下呼吸道感染的价值。 方法 选取AECOPD合并下呼吸道感染患者250例为AECOPD组,另选取正常体检人群100例为对照组。AECOPD组给予常规抗感染、止咳化痰、平喘及吸氧等治疗。比较2组生命体征指标(体温、心率、白细胞计数及中性粒细胞百分比)、实验室指标［SAA、C反应蛋白(CRP)、前白蛋白(PA)、CRP/PA］。采用受试者工作特征(ROC)曲线分析血清SAA、CRP/PA早期诊断AECOPD合并下呼吸道感染的价值。 结果 AECOPD组心率、白细胞计数及中性粒细胞百分比均高于对照组,差异有统计学意义(P<0.01)。治疗前, AECOPD组血清SAA、CRP、CRP/PA水平高于对照组, PA水平低于对照组,差异均有统计学意义(P<0.01); 治疗后, AECOPD组血清SAA、CRP、CRP/PA降低, PA水平升高,差异均有统计学意义(P<0.01)。ROC曲线分析结果显示, SAA、CRP/PA诊断AECOPD合并下呼吸道感染的曲线下面积(AUC)分别为0.829、0.862, 敏感性和特异性分别为84.54%、83.43%和79.87%、87.66%。 结论 血清SAA、CRP/PA可作为早期诊断AECOPD合并下呼吸道感染的有效生物标志物,均具有较高的敏感性和特异性。
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关键词:
- 血清淀粉样蛋白A /
- C反应蛋白 /
- 前白蛋白 /
- 慢性阻塞性肺疾病急性加重期 /
- 下呼吸道感染
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