Progress of methods for early prediction and screening of neonatal hyperbilirubinemia
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摘要: 新生儿黄疸是最常见的新生儿疾病,多数患儿预后良好,少数新生儿可发展为高胆红素血症,病情严重者还可发生急性胆红素脑病及核黄疸,威胁新生儿生命安全。降低急性胆红素脑病发病率的关键在于预防重度高胆红素血症的发生,因此新生儿高胆红素血症的早期预测及筛查、风险因素评估是新生儿科研究的热点。目前,临床仍缺少预测新生儿高胆红素血症的敏感性高的单一因素,仍需要联合其他危险因素进行分析。本研究对新生儿高胆红素血症的发病因素、早期预测因子、早期筛查方法进行综述,以期提高新生儿高胆红素血症的预防和治疗效果。Abstract: Neonatal jaundice is the most common neonatal disease, the prognosis of most children are good, but a few newborns can develop into hyperbilirubinemia, and severe cases can also have acute bilirubin encephalopathy and nuclear jaundice, which can threaten the life safety of newborns. The key procedure to reduce the incidence of acute bilirubin encephalopathy is to prevent the occurrence of severe hyperbilirubinemia. Therefore, early prediction and screening of neonatal hyperbilirubinemia and risk factors assessment are the focus of research in the department of neonatology. At present, there is still a lack of single factor with high sensitivity in predicting neonatal hyperbilirubinemia, and it still needs to be combined with other risk factors for analysis. This study reviewed the risk factors, early predictors and early screening methods of neonatal hyperbilirubinemia in order to improve the prevention and treatment effect of neonatal hyperbilirubinemia.
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