Application of ultrasound examination of thickness of the translucent tissue in the neck of fetus combined with detection of serological indexes in prenatal screening in early pregnancy
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摘要: 目的 探讨胎儿颈部半透明组织厚度(NT)超声联合血清学指标检测在孕早期胎儿染色体异常产前筛查中的应用价值。 方法 选择正常产检的1 855例孕妇作为研究对象,孕早期均进行胎儿NT超声检查和血清学指标检查,以随访结果作为“金标准”,比较胎儿NT超声、血清学指标检查和两者联合检查对胎儿染色体异常的筛查结果差异。 结果 1 855例孕妇无1例脱落。随访结果显示,本组共出现染色体异常9例(21-三体异常4例, 18-三体异常3例, 13-三体异常2例); 胎儿NT超声联合血清学指标检查对孕早期胎儿染色体异常筛查的敏感度、特异度、阳性预测值和阴性预测值均高于单独血清学指标检查、单独胎儿NT超声检查,且联合检查结果与随访结果的一致性更高。 结论 在孕早期胎儿染色体异常产前筛查中,胎儿NT超声检查联合血清学指标检查可提高筛查效能。
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关键词:
- 孕早期 /
- 染色体异常 /
- 产前筛查 /
- 胎儿颈部半透明组织厚度超声 /
- 血清学指标
Abstract: Objective To explore the value of ultrasound examination of thickness of the translucent tissue in the neck of fetus combined with detection of serological indicators in prenatal screening of fetal chromosomal abnormalities in early pregnancy. Methods A total of 1 855 cases with routine prenatal check-up were selected as research objects, and were performed NT ultrasound examinations and detection of serological indexes. Taking maternal follow-up results as gold standard, the screening results for fetal chromosomal abnormalities by fetal NT ultrasound examination or serological detection alone, and the joint detection were compared. Results All the 1 855 pregnant women completed the study. The follow-up results showed that there were 9 cases with abnormal staining, including 4 cases with abnormity of trisomy 21, 3 cases with abnormity of trisomy 18 and 2 cases with abnormity of trisomy 13. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of fetal NT ultrasound combined with detection of serological indicators in early pregnancy were higher than those of detection of serological indicators or fetal NT ultrasound alone, and the combined test had higher consistency with follow-up results. Conclusion Fetal NT ultrasound examination combined with detection of serological indicators can improve the diagnostic efficacy in prenatal screening of fetal chromosomal abnormalities in early pregnancy. -
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虢玉芹. B超联合母体血清AFP、Freeβ-hCG、uE3检测在筛查胎儿中枢神经系统畸形的价值[J]. 中国计划生育学杂志, 2018, 26(10):954-957. 王蓉蓉. 血清Free-β-HCG、PAPP-A、uE3联合NT在孕早期胎儿染色体异常筛查中的价值分析[J]. 中国优生与遗传杂志, 2019, 27(7):777-779 , 787.
张利, 陈咏玫, 马瑶, 等. 超声NT检查联合孕妇血清uE3、Inhibin-A检测用于21-三体综合征筛查的意义[J]. 中国妇幼保健, 2019, 34(15):3603-3606. 胡成子, 杨若云, 李敏文. 超声NT指标与母体血清学筛查在胎儿21-三体综合征产前诊断中的价值[J]. 中国优生与遗传杂志, 2019, 27(9):1054-1056 , 1062.
陈丽军, 孟倩. 孕中期胎儿超声软指标与血清学筛查在产前诊断21-三体综合征中的临床价值[J]. 中国优生与遗传杂志, 2019, 27(9):1063-1065. 潘宏贵, 林庆芳, 梁萍, 等. 孕中期4种产前诊断指征与胎儿异常染色体核型相关性及有创穿刺综合成功率探讨[J]. 中国妇幼保健, 2019, 34(17):4018-4020. 刘琼娜, 高悦. 妊娠早期超声联合血清Fβ-hCG与uE3及AFP诊断21-三体综合征的临床价值[J]. 解放军预防医学杂志, 2019, 37(11):102-103. 李源, 刘迎平, 阮焱. 孕早期血清学联合超声NT筛查胎儿染色体异常的研究[J]. 中国妇幼保健, 2018, 33(13):3097-3098. 宋筱玉, 唐中锋, 林晓娟, 等. 超声联合血清甲胎蛋白、游离β绒毛膜促性腺激素水平检测对孕中期胎儿染色体异常诊断特异度及阳性检出率的影响[J]. 中国妇幼保健, 2018, 33(17):3955-3958.
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