Kuntai Capsule versus femoston in the treatment of patients with climacteric syndrome
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摘要: 目的 比较坤泰胶囊与芬吗通治疗更年期综合征患者的效果。 方法 将80例更年期综合征患者随机分为观察组(n=40)与对照组(n=40)。对照组患者使用芬吗通治疗,观察组患者使用坤泰胶囊治疗。比较2组患者治疗前后血脂指标［甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)］水平、性激素指标［雌二醇(E2)、黄体生成素(LH)、卵泡刺激素(FSH)］水平及不良反应发生情况。 结果 治疗12周后, 2组TG、TC、LDL-C、HDL-C水平均较治疗前显著改善,且观察组TG、TC、LDL-C水平显著低于对照组, HDL-C水平显著高于对照组(P<0.05)。治疗12周后, 2组E2、LH、FSH水平均较治疗前显著改善,且观察组E2水平显著高于对照组,LH、FSH水平显著低于对照组(P<0.05)。观察组不良反应发生率为7.50%, 与对照组的17.50%比较,差异无统计学意义(P>0.05)。 结论 坤泰胶囊治疗更年期综合征患者的临床效果显著优于芬吗通,其不仅能够有效调节患者血脂与性激素水平,且不良反应较少。Abstract: Objective To compare the effect of Kuntai Capsule and femoston in the treatment of patients with climacteric syndrome. Methods Totally 80 patients with climacteric syndrome were randomly divided into observation group(n=40)and control group(n=40). The control group was treated with femoston, and the observation group was treated with Kuntai Capsule. The levels of blood lipid indexes ［triglyceride(TG), high density lipoprotein cholesterol(HDL-C), total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)］, sex hormone indexes ［estradiol(E2), luteinizing hormone(LH)and follicle stimulating hormone(FSH)］ and adverse reactions were compared before and after treatment between the two groups. Results After 12 weeks of treatment, the levels of TG, TC, LDL-C and HDL-C in both groups were significantly improved, the levels of TG, TC, LDL-C in the observation group were significantly lower than those in the control group, and the HDL-C level was significantly higher than that in the control group(P<0.05). After 12 weeks of treatment, the levels of E2, LH and FSH in both groups were significantly improved when compared with those before treatment, and the level of E2 in the observation group was significantly higher than that in the control group, while the levels of LH and FSH were significantly lower than those in the control group(P<0.05). The incidence of adverse reactions in the observation group was 7.50%, which showed no significant difference compared to 17.50% in the control group(P>0.05). Conclusion Clinical effect of Kuntai Capsule is significantly better than that of femoston in the treatment of patients with climacteric syndrome, which can not only effectively regulate the levels of blood lipid indexes and sex hormone indexes, but also has less adverse reactions.
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