Effect observation of Huangqi Buxue Decoction combined with Salvia Miltiorrhiza and Ligustrazine Injection in the treatment of elderly patients with H-type hypertension complicated with acute cerebral infarction
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摘要: 目的 观察黄芪补血汤联合丹参川芎嗪注射液治疗老年H型高血压合并急性脑梗死患者的疗效。 方法 将131例老年H型高血压合并急性脑梗死患者随机分为2组,对照组65例给予丹参川芎嗪注射液治疗,观察组66例在对照组基础上加用黄芪补血汤治疗。比较2组患者的治疗效果、血压、同型半胱氨酸(Hcy)水平、血液流变学指标、神经功能指标及药物安全性。 结果 治疗后,观察组血压、Hcy均低于对照组,差异有统计学意义(P<0.05)。观察组血液流变学指标均低于对照组,差异有统计学意义(P<0.05)。观察组美国国立卫生研究院卒中量表(NIHSS)评分低于对照组, Barthel指数及肢体运动功能量表(FMA)评分高于对照组,差异有统计学意义(P<0.05)。对照组不良反应发生率为7.69%, 观察组为6.06%, 差异无统计学意义(P>0.05)。 结论 黄芪补血汤联合丹参川芎嗪注射液能有效降低H型高血压合并急性脑梗死患者血压及Hcy水平,改善血液流变学,减轻神经功能损伤,提高患者日常生活能力及运动功能。Abstract: Objective To explore the effect of Huangqi Buxue Decoction combined with Salvia Miltiorrhiza and Ligustrazine Injection in the treatment of elderly patients with H-type hypertension complicated with acute cerebral infarction. Methods Totally 131 elderly patients with H-type hypertension complicated with acute cerebral infarction were randomly divided into two groups, 65 cases in the control group were treated with Salvia Miltiorrhiza and Ligustrazine Injection, and 66 cases in the observation group were treated with Huangqi Buxue Decoction on the basis of the control group. The therapeutic effect, blood pressure, homocysteine(Hcy)level, hemorheology indexes, nerve function indexes and drug safety were compared between the two groups. Results After treatment, the blood pressure and Hcy level of the observation group were significantly lower than those of the control group(P<0.05). The hemorheology indexes of the observation group were significantly lower than those of the control group(P<0.05). The National Institutes of Health Stroke Scale(NIHSS)score of the observation group was significantly lower than that of the control group, the Barthel index and Fugel-Meyer(FMA)score of the observation group were significantly higher than those of the control group(P<0.05). The incidence of adverse reactions in the control group was 7.69%, which showed no significant difference compared with 6.06% in the observation group(P>0.05). Conclusion Huangqi Buxue Decoction combined with Salvia Miltiorrhiza and Ligustrazine Injection can effectively reduce blood pressure and Hcy level in patients with H-type hypertension complicated with acute cerebral infarction, improve hemorheology, alleviate the nerve function damage, and improve the daily - living ability and motor function of patients.
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