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老年原发性高血压患者早期肾损伤的4项指标联合检测价值

张俊峰, 柳胜贤, 李捷

张俊峰, 柳胜贤, 李捷. 老年原发性高血压患者早期肾损伤的4项指标联合检测价值[J]. 实用临床医药杂志, 2020, 24(14): 97-99. DOI: 10.7619/jcmp.202014026
引用本文: 张俊峰, 柳胜贤, 李捷. 老年原发性高血压患者早期肾损伤的4项指标联合检测价值[J]. 实用临床医药杂志, 2020, 24(14): 97-99. DOI: 10.7619/jcmp.202014026
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ZHANG Junfeng, LIU Shengxian, LI Jie. Value of combined detection of four indicators in diagnosis of early renal injury in elderly patients with essential hypertension[J]. Journal of Clinical Medicine in Practice, 2020, 24(14): 97-99. DOI: 10.7619/jcmp.202014026
Citation: ZHANG Junfeng, LIU Shengxian, LI Jie. Value of combined detection of four indicators in diagnosis of early renal injury in elderly patients with essential hypertension[J]. Journal of Clinical Medicine in Practice, 2020, 24(14): 97-99. DOI: 10.7619/jcmp.202014026
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老年原发性高血压患者早期肾损伤的4项指标联合检测价值

  • 1. 河南省宜阳县人民医院 检验科, 河南 宜阳, 471600;

  • 2. 郑州大学附属洛阳中心医院 生殖医学科, 河南 郑州, 471000;

  • 3. 河南科技大学第二附属医院 检验科, 河南 郑州, 471000

详细信息

  • 中图分类号: R544.1

Value of combined detection of four indicators in diagnosis of early renal injury in elderly patients with essential hypertension

  • 1. Department of Clinical Laboratory, Yiyang County People's Hospital of He'nan Province, Yiyang, He'nan, 471600;

  • 2. Department of Reproductive Medicine, Luoyang Central Hospital Affiliated to Zhengzhou University, Zhengzhou, He'nan, 471000;

  • 3. Department of Laboratory Medicine, Second Affiliated Hospital of He'nan University of Science and Technology, Zhengzhou, He'nan, 471000

摘要

    摘要
  • 摘要: 目的 探讨血清C反应蛋白(CRP)、血尿酸(UA)、血α1-微球蛋白(α1-MG)与尿α1-MG联合检测诊断老年原发性高血压患者早期肾损伤的价值。 方法 选取老年原发性高血压患者80例,根据尿α1-MG检测结果分为早期肾损伤组(n=37)和单纯高血压组(n=43)。另选取38例无高血压的健康体检者为对照组。比较3组患者肾功能指标,分析尿α1-MG水平与肾功能指标的相关性,比较不同检测指标的诊断效能。 结果 早期肾损伤组尿α1-MG、血清CRP、血UA、血α1-MG均显著高于其他2组(P<0.05),单纯高血压组尿α1-MG、血清CRP、血UA、血α1-MG均显著高于对照组(P<0.05)。相关性分析结果显示,尿α1-MG与血清CRP、血UA、血α1-MG均显著正相关(r=0.858、0.610、0.908,P=0.001、0.001、0.001)。血清3项联合检测与4项联合检测诊断原发性高血压早期肾损伤的灵敏度差异有统计学意义(P<0.05),而特异度、准确度比较差异无统计学意义(P>0.05)。 结论 血清CRP、血UA、血α1-MG和尿α1-MG联合检测可显著提高老年原发性高血压患者早期肾损伤的诊断灵敏度,可反映老年原发性高血压患者早期肾损伤的程度。
    Abstract: Objective To explone the value of combined detection of blood C reactive protein(CRP), uric acid(UA), α1-microglobulin(α1-MG)and urine α1-MG in diagnosis of early renal damage in elderly patients with essential hypertension. Methods A total of 80 elderly patients with essential hypertension were selected, and were divided into early renal injury group(n=37)and simple hypertension group(n=43)according to the urine α1-MG test results. Another 38 healthy patients without hypertension were selected as control group. Renal function indexes were compared, correlation between urine α1-MG and renal function was analyzed, and diagnostic efficacy of different indicators were compared. Results Urine α1-MG, blood CRP, blood UA, and blood α1-MG in the early renal injury group were significantly higher than those in another two groups(P<0.05), and were significantly higher in the simple hypertension group than those in the control group(P<0.05). Correlation analysis showed that urine α1-MG was positively correlated with blood CRP, blood UA, and blood α1-MG(r=0.858, 0.610, 0.908; P=0.001, 0.001, 0.001). Combined detection of four indicators and three indicators showed significant difference in sensitivity(P<0.05), and - no statistically significant differences in specificity and accuracy(P>0.05). Conclusion Detection of blood CRP, UA, blood α1-MG and urine α1-MG in combination can reflect early renal damage degree in elderly patients with essential hypertension, and significantly improve the sensitivity.
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    • 参考文献(10)
  • 傅娟, 周燕, 刘小香. 血和尿中生化指标检测在老年原发性高血压患者早期肾损伤诊断中的意义[J]. 中国卫生检验杂志, 2019, 29(7): 816-817

    , 822.
    臧学峰, 古旭云, 赵磊, 等. 尿微量白蛋白及尿α1-微球蛋白对严重脓毒症患者急性肾损伤早期诊断价值[J]. 中国实验诊断学, 2018, 22(6): 1006-1009.
    王纯静, 李金艳, 何文丽, 等. 妊娠高血压综合征并发肾损伤患者血清生化指标水平变化及其早期诊断价值[J]. 海南医学, 2019, 30(18): 2383-2386.
    宋喆. 高血压性肾脏病的发病机理与诊断治疗[J]. 临床医药文献电子杂志, 2018, 61(4): 12064-12066.
    袁会玲, 张晓华, 杨洪霞, 等. 血浆肾素-血管紧张素-醛固酮系统活性与原发性高血压患者靶器官损害的相关性[J]. 中国老年学杂志, 2018, 38(24): 5889-5892.
    阮志, 李华. 原发性高血压和肾功能减退的相关性[J]. 中华高血压杂志, 2017, 25(1): 22-26.
    吴三五, 陈昆. CysC与hs-CRP对冠状动脉介入术后对比剂急性肾损伤的诊断价值[J]. 国际检验医学杂志, 2019, 40(17): 2103-2106.
    佘剑雄, 陆国玉, 陶言言. 乌司他丁联合血液灌流治疗急性百草枯中毒所致肾损伤的效果和预后[J]. 华中科技大学学报: 医学版, 2019, 48(6): 714-718.
    王晨晨. UAlb/UCr、α1-MG、CRP联合检测在早期糖尿病肾病诊断中应用分析[J]. 糖尿病天地, 2019, 16(9): 107-108.
    于鹏艳. 血必净防治急性百草枯中毒致肾损伤的效果及作用机制分析[J]. 医学临床研究, 2017, 34(3): 521-523.
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  • 收稿日期:  2020-03-18

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