Clinical analysis of hyperbaric oxygen combined with vitamin C in patients with ACOP and its effect on myocardial markers and antioxidant levels
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摘要: 目的 探讨高压氧联合维生素C治疗急性一氧化碳中毒(ACOP)患者的临床疗效及其对心肌标志物、抗氧化水平的影响。 方法 按随机数字表法将46例ACOP患者分为2组,每组23例。对照组予以高压氧治疗,观察组在对照组基础上增加维生素C治疗。观察2组治疗总有效率,治疗前后肌酸激酶同工酶(CK-MB)、脑钠肽(BNP)、心肌肌钙蛋白I(cTnI)水平,治疗前后过氧化氢酶(CAT)及血清脂质过氧化物(LPO)水平。 结果 观察组治疗总有效率为95.65%, 显著高于对照组的73.91%(P<0.05); 观察组治疗后CK-MB、BNP及cTnI水平均显著低于对照组(P<0.05); 观察组治疗后CAT及LPO水平均显著低于对照组(P<0.05)。 结论 高压氧联合维生素C治疗ACOP患者可以提高疗效,减少自由基,缩短住院时间。Abstract: Objective To explore effect of hyperbaric oxygen combined with vitamin C in the treatment of patients with acute carbon monoxide poisoning(ACOP)and its effects on myocardial markers and antioxidant levels. Methods According to the random number table method, 46 patients with ACOP were divided into two groups, with 23 cases in each group. The control group was treated with hyperbaric oxygen, while the observation group was additionally given vitamin C on the basis of the control group. The total clinical efficacy, the levels of creatine kinase isoenzyme(CK-MB), brain natriuretic peptide(BNP), cardiac troponin I(cTnI)before and after treatment, catalase(CAT)and serum lipid peroxide(LPO)before and after treatment were observed. Results The total effective rate in the observation group was 95.65%, which was significantly higher than 73.91% in the control group(P<0.05); the levels of CK-MB, BNP and cTnI in the observation group were significantly lower than those in the control group(P<0.05); levels of LPO and CAT after treatment in the observation group were significantly lower than those in the control group(P<0.05). Conclusion Hyperbaric oxygen combined with vitamin C in patients with ACOP can improve the efficacy, reduce free radicals, and shorten the length of hospital stay.
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