四氢生物蝶呤与恶性肿瘤关系的研究进展

朱彩云; 陈勇

doi:10.7619/jcmp.202008034

四氢生物蝶呤与恶性肿瘤关系的研究进展

朱彩云¹,
陈勇^2, ,

1. 扬州大学, 江苏扬州, 225000;
2. 扬州大学临床医学院肿瘤科, 江苏扬州, 225000

基金项目:

国家自然科学基金(81302015)

江苏省自然科学基金(BK20191218)

详细信息

通讯作者:
陈勇,E-mail:chenyong_jsyz@sina.com

中图分类号: R730.23
计量
- 文章访问数: 386
- HTML全文浏览量: 100
- PDF下载量: 27
出版历程
- 收稿日期: 2020-02-04

Research advance on relationship between tetrahydrobiopterin and tumor

ZHU Caiyun¹,
CHEN Yong^2, ,

1. Yangzhou University, Yangzhou, Jiangsu, 225000;
2. Department of Oncology, School of Clinical Medicine of Yangzhou University, Yangzhou, Jiangsu, 225000

摘要

摘要: 恶性肿瘤是严重威胁人类生命与健康的疾病,且发病率逐年增高。恶性肿瘤的发生机制复杂,是一个多因子、多步骤的过程。四氢生物蝶呤(BH4)是芳香族氨基酸羟化酶及一氧化氮合酶的辅酶,具有抗氧化和清除活性氮氧化物的功能,在体内一系列生理和病理过程中起关键作用。近年来有研究表明,BH4在恶性肿瘤的发生发展中起作用,具有促进和抑制恶性肿瘤发生发展的双重作用。
- 四氢生物蝶呤 /
- 恶性肿瘤 /
- 分子机制
Abstract: Cancer threatens human's life and its incidence is increasing year by year. The pathogenesis of cancer is complex, and its occurrence is the result of multi-factor interaction and multistage process. With the functions of anti-oxidation and removing active nitrogen oxides, tetrahydrobiopterin(BH4)is a coenzyme of aromatic amino acid hydroxylase and nitric oxide synthase, and plays a key role in a series of physiological and pathological process in vivo. Recent studies has shown that BH4 plays a role in the occurrence and development of malignant tumor, and has double functions in promoting and inhibiting the development of tumor.
- tetrahydrobiopterin /
- malignant tumor /
- molecular mechanism

HTML全文

参考文献(35)

Heron M. Deaths: leading causes for 2016[J]. Natl Vital Stat Rep, 2018, 67(6): 1-77.

Al-Shaheri F N, Al-Shami K M, Gamal E H, et al. Association of DNA repair gene polymorphisms with colorectal cancer risk and treatment outcomes[J]. ExpMolPathol, 2020, 113: 104364.

向雨, 郑小鹏, 冯婧, 等. 原发性肝癌患者血清肿瘤标志物与肿瘤组织中凋亡调节基因的表达[J]. 黑龙江医药科学, 2019, 42(4): 4-5

, 12.

Singh S, Hassan D, Aldawsari H M, et al. Immune checkpoint inhibitors: a promising anticancer therapy[J]. Drug Discov Today, 2020, 25(1): 223-229.

Chen L Y, Zeng X, Wang J H, et al. Roles of tetrahydrobiopterin in promoting tumor angiogenesis[J]. AmJPathol, 2010, 177(5): 2671-2680.

Werner E R, Blau N, Thöny B. Tetrahydrobiopterin: biochemistry and pathophysiology[J]. Biochem J, 2011, 438(3): 397-414.

Kaneko Y S, Mori K, Nakashima A, et al. Determination of tetrahydrobiopterin in murine locus coeruleus by HPLC with fluorescence detection[J]. Brain ResBrain Res Protoc, 2001, 8(1): 25-31.

代佑果, 崔进, 甘平, 等. 外源性四氢生物蝶呤改善小鼠颈总动脉内膜损伤的实验研究[J]. 临床心血管病杂志, 2015, 31(8): 883-887.

Scheffer D, Lenfers B, Cronin S, et al. Inhibition of tetrahydrobiopterin production compromises T cell mitochondrial bioenergetics and reduces abdominal pain[J]. Free Radical Biology and Medicine, 2019, 145: S94-S94.

田静朴, 李俭强, 李为民. 四氢生物蝶呤与心血管疾病关系的研究进展[J]. 医学综述, 2015, 21(22): 4061-4064.

姚顺, 吴少虹, 柏勇平, 等. GTP环化水解酶Ⅰ/四氢生物蝶呤通路对高血压内皮祖细胞体外活性和体内再内皮化能力的调节[J]. 中国动脉硬化杂志, 2018, 26(3): 265-272.

张正义, 关晓丽, 卢昌宏, 等. 四氢生物蝶呤对大鼠急性心肌缺血再灌注损伤的保护作用及其机制研究[J]. 现代药物与临床, 2016, 31(6): 752-756.

Chuaiphichai S, McNeill E, Douglas G, et al. Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation[J]. Hypertension, 2014, 64(3): 530-540.

Engineer A, Lim Y J, Lu X R, et al. Sapropterin reduces coronary artery malformation in offspring of pregestational diabetes mice[J]. Nitric Oxide, 2020, 94: 9-18.

Mühl H, Pfeilschifter J. Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1 beta-stimulated rat glomerular mesangial cells[J]. Kidney Int, 1994, 46(5): 1302-1306.

Mori K, Nakashima A, Nagatsu T, et al. Effect of lipopolysaccharide on the gene expression of the enzymes involved in tetrahydrobiopterin de novo biosynthesis in murine neuroblastoma cell line N1E-115[J]. NeurosciLett, 1997, 238(1/2): 21-24.

王卓飞, 陈锦文, 铁璐, 等. 四氢生物蝶呤的合成及其生物学功能[J]. 生理科学进展, 2015, 46(4): 259-264.

Leiva A, Fuenzalida B, Salsoso R, et al. Tetrahydrobiopterin Role in human umbilical vein endothelial dysfunction in maternal supraphysiological hypercholesterolemia[J]. BBA-Molecular Basis of Disease, 2016, 1862(4): 536-544.

Miclescu A, Gordh T. Nitric oxide and pain: "Something old, something new"[J]. Acta AnaesthesiolScand, 2009, 53(9): 1107-1120.

Stewart C R, Obi N, Epane E C, et al. Effects of diabetes on salivary gland protein expression of tetrahydrobiopterin and nitric oxide synthesis and function[J]. JPeriodontol, 2016, 87(6): 735-741.

Xie L, Hu D, Qin H, et al. In vivo gum Arabic-coated tetrahydrobiopterin protects against myocardial ischemia reperfusion injury by preserving Enos coupling[J]. Life Sci, 2019, 219: 294-302.

Moore B J R, Islam B, Ward S, et al. Repurposing of tranilast for potential neuropathic pain treatment by inhibition of sepiapterin reductase in the BH4pathway[J]. ACS Omega, 2019, 4(7): 11960-11972.

Dikalova A, Aschner J L, Kaplowitz M R, et al. Tetrahydrobiopterin oral therapy recouples Enos and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs[J]. AmJPhysiol Lung CellMolPhysiol, 2016, 311(4): L743-L753.

Dai Y G, Cui J, Gan P, et al. Downregulation of tetrahydrobiopterin inhibits tumor angiogenesis in BALB/c-nu mice with hepatocellular carcinoma[J]. OncolRep, 2016, 36(2): 669-675.

Ziche M, Morbidelli L. Molecular regulation of tumour angiogenesis by nitric oxide[J]. Eur Cytokine Netw, 2009, 20(4): 164-170.

Zhao Q, Zheng K, Ma C M, et al. PTPS facilitates compartmentalized LTBP1 S-nitrosylation and promotes tumor growth under hypoxia[J]. MolCell, 2020, 77(1): 95-107.

李婧, 冯娟, 王宪. 一氧化氮相关的巯基亚硝基化修饰及其对血管功能的调控[C] //庆祝《生理学报》创刊90周年大会论文集. 无锡, 2017: 41-54.

林惠昆, 李翠, 柯学. NO参与的S-亚硝基化反应及其生理意义[J]. 安徽农学通报, 2009, 15(10): 48-50.

李静, 柳斌, 樊均明. TGF-β在足细胞生理功能及病理损伤中的作用[J]. 中国中西医结合肾病杂志, 2011, 12(12): 1120-1122.

Syed V. TGF-βsignaling in cancer[J]. J Cell Biochem, 2016, 117(6): 1279-1287.

Seoane J, Gomis R R. TGF-βfamily signaling in tumor suppression and cancer progression[J]. Cold Spring HarbPerspect Biol, 2017, 9(12): a022277.

Lack J, O'Leary J M, Knott V, et al. Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta[J]. JMolBiol, 2003, 334(2): 281-291.

Drews F, Knöbel S, Moser M, et al. Disruption of the latent transforming growth factor-beta binding protein-1 gene causes alteration in facial structure and influences TGF-beta bioavailability[J]. BiochimBiophysActa, 2008, 1783(1): 34-48.

Cronin S J F, Seehus C, Weidinger A, et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer[J]. Nature, 2018, 563(7732): 564-568.

Melo F, Sousa R, SoarelJ, et al. Contribution of Tetrahydrobiopterin(BH4)Throughout Tumor Progression: Positive or Negative Regulator of Melanoma Genesis?[J]. Free Radical Biology and Medicine, 2019, 145(Supl1): S72.