枳朴六君子汤联合序贯疗法对中晚期胃癌患者T淋巴细胞亚群的影响

谢燕华; 陈捷

doi:10.7619/jcmp.202008012

枳朴六君子汤联合序贯疗法对中晚期胃癌患者T淋巴细胞亚群的影响

谢燕华,
陈捷^,

陕西省中医医院肿瘤科, 陕西西安, 710003

详细信息

通讯作者:
陈捷,E-mail:chenj0509@163.com

中图分类号: R735.2
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出版历程
- 收稿日期: 2020-02-04

Effects of Zhipo Liujunzi Decoction combined with sequential treatment on T lymphocyte subsets in patients with middle or advanced stage gastric cancer

XIE Yanhua,
CHEN Jie^,

Department of Oncology, Shaanxi Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi, 710003

摘要

摘要: 目的分析枳朴六君子汤联合序贯疗法对中晚期胃癌患者T淋巴细胞亚群的影响。方法选择本院住院治疗的112例中晚期胃癌患者为研究对象,根据随机数字表法将其分为对照组和实验组,各56例。对照组给予序贯治疗,实验组给予枳朴六君子汤联合序贯治疗,对比2组临床疗效、血清肿瘤标志物、T淋巴细胞亚群因子、毒副反应发生率。结果实验组临床总有效率为89.29%,显著高于对照组的64.29%(P<0.05); 实验组治疗3个疗程后CD3⁺、CD4⁺、CD4⁺/CD8⁺均显著高于对照组(P<0.05); 实验组毒副反应发生率低于对照组(P<0.05); 实验组治疗3个疗程后血清糖类抗原-724(CA-724)、癌胚抗原(CEA)、糖类抗原-199(CA-199)因子均显著低于对照组(P<0.05)。结论枳朴六君子汤联合序贯疗法可有效抑制中晚期胃癌患者肿瘤病灶生长,改善免疫功能,抑制血清肿瘤标志物,降低毒副反应发生率。
- 枳朴六君子汤 /
- 胃癌 /
- 临床疗效 /
- T淋巴细胞亚群 /
- 毒副反应
Abstract: Objective To analyze effects of Zhipo Liujunzi Decoction combined with sequential treatment on T lymphocyte subsets in patients with middle or advanced stage gastric cancer. Methods A total of 112 patients with middle or advanced gastric cancer hospitalized in our hospital were selected, and were divided into control group(n=56)and study group(n=56)according to random number table method. The control group was given sequential treatment, while the control group was treated with Zhipo Liujunzi Decoction combined with sequential treatment, and the clinical efficacy, serum tumor markers, T lymphocyte subgroup factors, and incidence of toxic and side effects were compared between the two groups. Results The total clinical effective rate in the experimental group was significantly higher than that in the control group(89.29% vs. 64.29%, P<0.05). After 3 courses of treatment, the levels of CD3⁺, CD4⁺, and CD4⁺/CD8⁺ in the experimental group were significantly higher than those of the control group(P<0.05). The incidence of toxic side effects in the experimental group was significantly lower than the control group(P<0.05). The levels of serum carbohydrate antigen-724(CA-724), carcinoembryonic antigen(CEA), carbohydrate antigen-199(CA-199)in the experimental group were significantly lower than that of the control group after 3 courses of treatment(P<0.05). Conclusion Zhipo Liujunzi Decoction combined with sequential treatment can effectively inhibit the growth of tumor lesions, improve immune function, suppress serum tumor markers, and reduce the incidence of toxic and side effects in patients with middle or advanced stage gastric cancer.
- Zhipo Liujunzi Decoction /
- gastric cancer /
- clinical efficacy /
- T lymphocyte subsets /
- toxic and side effects

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