Expression and significance of chemokine C-C-receptor 4 in colorectal cancer
-
摘要: 目的 探讨趋化因子C-C-基元受体4(CCR4)在结直肠癌中的表达及意义。 方法 选取在本院接受结直肠癌原发灶外科手术的患者共80例作为A组。另选取同期良性结直肠肿瘤患者75例作为B组。比较2组趋化因子受体CCR4在结直肠癌组织与良性结直肠肿瘤组织中的阳性检测率。分析相关临床病理因素与结直肠癌趋化因子受体CCR4阳性检测结果的关系。 结果 A组免疫组化法检测阳性例数、RT-PCR法检测阳性例数、PCR条带灰度比值均多于、高于B组,差异有统计学意义(P<0.05)。在结直肠癌组织(A组)中, CCR4阳性检测结果在性别、年龄、淋巴结转移、肝转移、分化程度、部位等临床病理因素中无显著差异(P>0.05), 在Duke分期中有显著差异(P<0.05)。 结论 结直肠癌组织中CCR4的异常表达可能有助于肿瘤诱导的免疫抑制。Abstract: Objective To investigate the expression and significance of chemokine C-C-receptor 4(CCR4)in colorectal cancer. Methods Totally 80 surgical specimens of primary colorectal cancer were selected as group A, and 75 patients with benign colorectal cancer were selected as group B. The positive detection rates of CCR4 in colorectal cancer and benign colorectal cancer were compared. The positive rates of CCR4 in colorectal cancer and benign colorectal cancer were compared. The relationship between clinicopathological factors and positive results of chemokine receptor CCR4 in colorectal cancer were analyzed. Results The number of positive cases detected by immunohistochemistry, the number of positive cases detected by RT-PCR and the gray ratio of PCR bands in group A were significantly higher than those in group B(P<0.05). In colorectal cancer(group A), there were no significant differences in CCR4 positive test results in gender, age, lymph node metastasis, liver metastasis, differentiation degree, location and other clinical pathological factors(P>0.05), and there were significant differences in CCR4 positive test results in Duke stage(P<0.05). Conclusion The abnormal expression of CCR4 in colorectal cancer may contribute to tumor-induced immunosuppression.
-
Keywords:
- chemokine /
- C-C-receptor 4 /
- colorectal cancer /
- expression /
- positive rate
-
-
Talay O, Marshall L, Meleza C, et al. Abstract 4600: Potent and selective C-C chemokine receptor(CCR4)antagonists potentiate anti-tumor immune responses by inhibiting regulatory T cells(Treg)[C] //Immunology, American Association for Cancer Research, 2017: 4600-4600.
Wilson G J, Hewit K D, Pallas K J, et al. Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland[J]. Development, 2017, 144(1): 74-82.
Kufareva I, Gustavsson M, Zheng Y, et al. What do structures tell us about chemokine receptor function and antagonism[J]. Annu Rev Biophys, 2017, 46: 175-198.
Menhaji-Klotz E, Hesp K D, Londregan A T, et al. Discovery of a novel small-molecule modulator of C-X-C chemokine receptor type 7 as a treatment for cardiac fibrosis[J]. J Med Chem, 2018, 61(8): 3685-3696.
El-Zaatari M, Zhang M, Kao J Y. 584-CXC chemokine receptor 2(CXCR2)deficiency in myeloidderived suppressor cells(MDSC's)exacerbates Helicobacter induced gastric spasmolytic peptide-expressing pseudopyloric Metaplasia(SPEM)and alters mucous cell characteristics in mice[J]. Gastroenterology, 2018, 154(6): S122-S123.
Chen Y, Chen Q J, Xie F F, et al. Traditional Chinese medicine extract from Huaier increases the expression of Duffy antigen receptor for chemokines and reduces the expression of its ligands[J]. Anal Cell Pathol(Amst), 2018, 2018: 6756092.
吴乐军, 戎瑞明, 吴应虬, 等. 肾癌各期患者调节性T细胞的表达[J]. 全科医学临床与教育, 2012, 10(4): 370-372, 封2. 杨励, 牛妍艳, 常瑛, 等. Tregs细胞CCR4的表达变化在复发性生殖器疱疹患者发病中的意义[J]. 中国皮肤性病学杂志, 2017, 31(12): 1297-1300 , 1320.
王东霞. Th1/Th2趋化因子及其受体在大疱性类天疱疮皮损中的表达[D]. 合肥: 安徽医科大学, 2018. 王伟, 柯善保, 刘明博, 等. CCR4对肝癌细胞索拉非尼放射敏感性及裸鼠成瘤的影响[J]. 中华放射肿瘤学杂志, 2019, 28(2): 136-139. 欧长波, 王秋霞, 张艳红, 等. IBDV感染对T细胞趋化因子受体及其配体基因表达的影响[J]. 中国兽医科学, 2017, 47(2): 222-226. 孙立华, 朱斌, 周艳彩, 等. Th17细胞表面CCR4、CCR6、CXCR3表达量检测对慢性乙型肝炎患者病情评估的价值[J]. 中国现代医学杂志, 2017, 27(3): 69-73. 付焱, 李恒, 黄东, 等. CXC趋化因子配体16/CXC趋化因子受体6在结肠癌组织的表达及对结肠癌增殖、侵袭、转移能力的影响[J]. 中华实验外科杂志, 2017, 34(7): 1198-1201. 马琪, 虞碧霞, 陈俊丰, 等. 膀胱癌组织RON蛋白与CXC趋化因子受体4蛋白的表达及临床意义[J]. 中华实验外科杂志, 2017, 34(12): 2275-2275. -
期刊类型引用(8)
1. 杨增芯，李伟章，翁玉龙，陈兵，陆鑫. 沙库巴曲缬沙坦对COPD合并心力衰竭患者心功能的影响. 临床合理用药. 2025(01): 1-3+7 . 
百度学术
2. 刘媛，王澎，聂静. 血清BNP、CRP、PCT水平对慢阻肺急性加重期患者并发心力衰竭的预测价值. 航空航天医学杂志. 2024(03): 270-273 . 百度学术
3. 周蓓，邱饶元. 慢性阻塞性肺疾病急性发作合并心力衰竭患者使用那屈肝素的临床效果研究. 现代诊断与治疗. 2024(13): 1932-1934+1966 . 百度学术
4. 冯双喜，袁天舒，林惠霞，伍利群. 不同标本类型中超敏C反应蛋白检验结果在脑瘫儿童感染性疾病治疗中的一致性分析. 中国医药指南. 2024(33): 41-43 . 百度学术
5. 康林，祝莹，高芸，黄瑾，李润洁. 血清降钙素、脑钠肽、心肌肌钙蛋白Ⅰ与老年肺炎病情严重程度的关系. 实用临床医药杂志. 2023(17): 93-96 . 本站查看
6. 缪雄，吉鹏，钱晶，陆洋. 低分子肝素联合卡维地络对COPD合并心力衰竭患者心肺功能和相关指标的影响. 中南医学科学杂志. 2022(05): 732-735 . 百度学术
7. 汪晶，彭博，王海存，崔晶，谭立业. 超滤联合注射用益气复脉治疗难治性心力衰竭的效果. 中国当代医药. 2022(28): 92-95 . 百度学术
8. 王小荣. 伊伐布雷定在COPD合并心力衰竭患者临床应用分析. 中外医疗. 2021(18): 94-97 . 百度学术
其他类型引用(1)
计量
- 文章访问数: 422
- HTML全文浏览量: 78
- PDF下载量: 7
- 被引次数: 9
下载:
苏公网安备 32100302010246号
