Expression of serum cortisol levels in post-stroke depression patients before and after treatment and its correlation with depression
-
摘要:目的 评价血清皮质醇水平在脑卒中后抑郁患者治疗前后的表达及其与抑郁的相关性。方法 随机选取本院收治的56例脑卒中后抑郁患者作为观察组, 选取同期收治的56例脑卒中未合并抑郁患者作为对照组。检测2组患者血清皮质醇水平，探讨其与脑卒中后抑郁的相关性。结果 观察组治疗前后血清皮质醇表达水平均高于对照组，差异有统计学意义(P < 0.05); 观察组治疗后汉密尔顿抑郁量表(HAMD)评分低于治疗前，差异有统计学意义(P < 0.05); Logistic线性回归分析表明，血清皮质醇与脑卒中后抑郁呈正相关。结论 血清皮质醇水平的表达与脑卒中后抑郁患者的发病有密切相关性。Abstract:Objective To evaluate the expression of serum cortisol in patients with post-stroke depression before and after treatment, and its correlation with depression.Methods A total of 56 patients with post-stroke depression admitted in our hospital were randomly selected as observation group and another 56 patients without depression in the same period were selected as control group. The serum cortisol level of the two groups was detected, and the correlation between the serum cortisol level and post-stroke depression were explored.Results The levels of serum cortisol expression in the observation group before and after treatment were significantly higher than that in the control group, and Hamilton Depression Scale(HAMD) scores of the observation group after treatment was lower than that in the control group (P < 0.05). Logistic linear regression analysis showed that the serum cortisol level was positively correlated with post-stroke depression.Conclusion The expression of serum cortisol level is closely correlated with the incidence of depression after stroke.
-
Keywords:
- serum cortisol /
- stroke /
- depression /
- Hamilton Depression Scale
-
-
[1] 罗强, 田春艳. 脑卒中患者早期应用抗抑郁药物治疗对提高康复治疗的作用研究[J]. 吉林医学, 2015, 36(15): 3266-3267. doi: 10.3969/j.issn.1004-0412.2015.15.033 [2] 王希佳. 脑卒中抑郁与神经功能缺损的相关性研究[J]. 医学综述, 2015, 21(21): 3996-3998. doi: 10.3969/j.issn.1006-2084.2015.21.055 [3] 王雨. 血清皮质醇水平与脑卒中后抑郁的相关性及其对治疗的指导意义[J]. 解放军医药杂志, 2015, 27(11): 85-88. doi: 10.3969/j.issn.2095-140X.2015.11.023 [4] 中华医学会神经病学分会. 中国急性缺血性脑卒中诊治指南2014[J]. 中华神经科杂志, 2015, 48(4): 246-257. doi: 10.3760/cma.j.issn.1006-7876.2015.04.002 [5] 孙振晓, 刘化学, 焦林瑛, 等. 医院焦虑抑郁量表的信度及效度研究[J]. 中华临床医师杂志: 电子版, 2017, 11(2): 198-201. doi: 10.3877/cma.j.issn.1674-0785.2017.02.005 [6] 姜天梦. 个体化健康教育对子宫瘢痕妊娠患者的影响[J]. 实用中西医结合临床, 2019, 19(9): 160-162. https://www.cnki.com.cn/Article/CJFDTOTAL-SZXL201909082.htm [7] 李莹, 李光校. 中国脑卒中患者抑郁患病率meta分析[J]. 中国公共卫生, 2015, 31(7): 968-972. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGW201507033.htm [8] 刘添, 余练. 氟哌噻吨美利曲辛配合帕罗西汀治疗脑卒中后抑郁的疗效观察[J]. 齐齐哈尔医学院学报, 2019, 40(12): 1489-1490. doi: 10.3969/j.issn.1002-1256.2019.12.016 [9] 楚丽萍, 张亚丽, 郭静, 等. 2型糖尿病并发脑卒中患者抑郁及影响因素分析[J]. 预防医学, 2019, 31(6): 586-588, 592. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYFX201906011.htm [10] 李小明, 胡爱虹, 顾群. 帕罗西汀和盐酸舍曲林治疗脑卒中后抑郁的临床疗效及安全性评价[J]. 中国临床药理学杂志, 2015, 31(10): 815-817. https://www.cnki.com.cn/Article/CJFDTOTAL-GLYZ201510015.htm [11] 叶文辉. 盐酸帕罗西汀治疗抑郁症的效果及不良反应观察[J]. 中外医学研究, 2019, 17(25): 138-140. https://www.cnki.com.cn/Article/CJFDTOTAL-YJZY201925059.htm [12] 张德龙, 饶燕, 廖院平. 宁心安神法联合盐酸舍曲林分散片对抑郁症患者睡眠质量的影响[J]. 江西中医药大学学报, 2019, 31(4): 53-54, 68. https://www.cnki.com.cn/Article/CJFDTOTAL-XYXB201904018.htm [13] 官国东, 陈敬毅, 宁为民. hs-CRP、补体C3、PA及皮质醇水平在脑卒中患者疾病进展中的变化[J]. 海南医学, 2016, 27(9): 1406-1409. doi: 10.3969/j.issn.1003-6350.2016.09.011 [14] 邓瑰丽. 急性缺血性脑卒中患者血清超敏C反应蛋白水平变化及其临床意义[J]. 中外医学研究, 2018, 16(25): 172-173. https://www.cnki.com.cn/Article/CJFDTOTAL-YJZY201825083.htm [15] 温友禄, 张新普, 徐海燕, 等. 抑郁症患者中医体质类型与皮质醇水平的关系[J]. 现代医院, 2018, 18(7): 1049-1051. doi: 10.3969/j.issn.1671-332X.2018.07.037 [16] 刘晓丹, 王颖, 黄力. 首发重性抑郁障碍患者大脑皮层厚度与血浆皮质醇水平的相关性研究[J]. 临床放射学杂志, 2015, 34(11): 1710-1714. https://www.cnki.com.cn/Article/CJFDTOTAL-LCFS201511002.htm
计量
- 文章访问数: 399
- HTML全文浏览量: 247
- PDF下载量: 10
下载:
苏公网安备 32100302010246号
