口服避孕药预防宫腔镜子宫内膜息肉切除术后复发的效果观察

张浩

doi:10.7619/jcmp.201918034

口服避孕药预防宫腔镜子宫内膜息肉切除术后复发的效果观察

张浩

广州医科大学附属广州市第一人民医院华南理工附属临床医学院妇科, 广东广州, 510120

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中图分类号: R711.74
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出版历程
- 收稿日期: 2019-07-19
- 录用日期: 2019-08-19
- 网络出版日期: 2021-02-28
- 发布日期: 2019-09-27

Effect of oral administration of contraceptives on prevention of recurrence after hysteroscopic endometrial polypectomy

ZHANG Hao

Department of Gynecology, Clinical Medical College of South China Science and Technology, First People's Hospital Affiliated to Guangzhou Medical University, Guangzhou, Guangdong, 510120

摘要

摘要:
目的探讨口服避孕药对宫腔镜子宫内膜息肉切除术后复发的预防效果。
方法选取240例子宫内膜息肉(EP)患者，采用随机数表法分为对照组和观察组，各120例。对照组患者单纯行宫腔镜子宫内膜息肉切除术治疗，干预组患者手术后口服复方短效避孕药治疗。观察2组术后3、6个月时血红蛋白(Hb)、子宫内膜厚度变化，并比较月经改善和EP复发情况。
结果 2组术后3、6个月时的血清Hb水平较术前显著升高，子宫内膜厚度显著下降(P < 0.05), 且观察组术后6个月时Hb水平显著高于对照组，子宫内膜厚度显著低于对照组(P < 0.05)。术后6个月时，观察组月经恢复正常率为91.67%, 显著高于对照组的78.33%(P < 0.05), 且观察组EP复发率4.17%, 显著低于对照组14.17%(P < 0.05)。
结论宫腔镜子宫内膜息肉切除术后口服短效避孕药，能提高患者血清Hb水平，抑制子宫内膜过度增生，对改善月经和预防EP复发效果显著。
- 子宫内膜息肉 /
- 宫腔镜子宫内膜息肉切除术 /
- 避孕药 /
- 复发 /
- 月经
Abstract:
Objective To investigate the effect of oral administration of contraceptives on prevention of recurrence after hysteroscopic endometrial polypectomy.
Methods A total of 240 patients with endometrial polyps (EP) were randomly divided into control group (n=120) and observation group (n=120). The control group was treated with hysteroscopic endometrial polypectomy alone, and the observation group was treated with compound short-acting contraceptives after operation. The changes of hemoglobin (Hb) and endometrial thickness were observed at 3 and 6 months after operation, and menstrual improvement and EP recurrence were compared between the two groups.
Results The serum Hb level increased significantly, and the endometrial thickness decreased significantly at 3 and 6 months after operation (P < 0.05), and the observation group changes more significantly at 6 months after operation than the control group(P < 0.05). The rate of returning to regular menstruation at 6 months after operation in the observation group was higher, and the recurrence rate of EP was lower than that in the control group(91.67% vs. 78.33%, 4.17%vs. 14.17, P < 0.05).
Conclusion Oral administration of short-acting contraceptives after hysteroscopic endometrial polypectomy can increase the level of serum Hb and inhibit endometrial hyperplasia, and play a positive role in improving menstruation and prevention of EP recurrence.
- endometrial polyps /
- hysteroscopic endometrial polypectomy /
- contraceptives /
- recurrence /
- menstruation

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表 1 2组不同时点血清Hb水平和子宫内膜厚度变化比较(x±s)

组别	n	血清Hb/(g/L)			子宫内膜厚度/cm
组别	n	术前	术后3个月	术后6个月	术前	术后3个月	术后6个月
对照组	120	108.25±11.07	112.36±11.28^*	117.70±10.95^*	1.49±0.37	0.70±0.15^*	1.05±0.27^*
观察组	120	108.41±10.92	114.20±11.51^*	121.62±9.87^*#	1.48±0.33	0.68±0.20^*	0.76±0.18^*#
Hb: 血红蛋白。与术前比较, *P < 0.05; 与对照组比较, #P < 0.05。

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表 2 2组术后6个月月经改善和EP复发情况比较[n(%)]

组别	n	月经恢复正常	EP复发
对照组	120	94(78.33)	17(14.17)
观察组	120	110(91.67)^*	5(4.17)^*
EP: 子宫内膜息肉。与对照组比较, *P < 0.05。

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参考文献(12)

[1]	李姬梅, 游金华, 焦海花. 醋酸环丙孕酮辅助宫腔镜子宫内膜息肉切除术对子宫内膜息肉的临床疗效[J]. 中国当代医药, 2017, 24(3): 148-149. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGUD201703029.htm
[2]	张园, 王珍. 口服避孕药及济生乌梅片对预防宫腔镜子宫内膜息肉切除术后子宫内膜息肉复发的影响[J]. 世界中西医结合杂志, 2018, 13(1): 44-47. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZX201801013.htm
[3]	邱华娟, 梁朵献, 孙颖, 等. 子宫内膜息肉中雌激素受体、血管内皮生长因子和转化生长因子-β1的表达及相关性研究[J]. 中国妇幼保健, 2017, 32(5): 928-930. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB201705018.htm
[4]	Landrum L M, Zuna R E, Walker J L. Endometrial Hyperplasia, Estrogen Therapy, and the Prevention of Endometrial Cancer[J]. Clinical Gynecologic Oncology, 2018, 47(18): 105-120. http://www.sciencedirect.com/science/article/pii/B9780323400671000048
[5]	翟翠静, 张红凯, 陈伟东, 等. 绝经前后子宫内膜息肉中肥大细胞类胰蛋白酶及类糜蛋白酶的表达及意义[J]. 解剖学报, 2017, 48(4): 466-470. https://www.cnki.com.cn/Article/CJFDTOTAL-JPXB201704018.htm
[6]	韩正枝. 孕激素辅助宫腔镜子宫内膜息肉切除术治疗子宫内膜息肉的临床疗效及对子宫内膜血管内皮生长因子表达的影响[J]. 贵州医药, 2017, 41(3): 294-296. doi: 10.3969/j.issn.1000-744X.2017.03.029
[7]	邓少君, 任红英, 邓小灵. 雌激素受体(ER)、孕激素受体(PR)与子宫内膜息肉形成的相关性研究[J]. 现代诊断与治疗, 2017, 28(8): 1508-1510. doi: 10.3969/j.issn.1001-8174.2017.08.086
[8]	董艳红, 吴而立. 宫腔镜联合屈螺酮炔雌醇对子宫内膜息肉患者子宫内膜厚度及月经情况的影响[J]. 医学理论与实践, 2018, 31(5): 709-711. https://www.cnki.com.cn/Article/CJFDTOTAL-YXLL201805049.htm
[9]	朱晨燕, 万晨东, 夏天. 宫腔镜子宫内膜息肉切除术后应用口服避孕药预防复发的效果观察[J]. 中国妇幼保健, 2018, 33(19): 4542-4544. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB201819075.htm
[10]	李利玲. 子宫内膜息肉术后放置左炔诺孕酮宫内缓释系统对预防复发的疗效[J]. 检验医学与临床, 2017, 14(12): 1744-1746. doi: 10.3969/j.issn.1672-9455.2017.12.022
[11]	乔峤, 李秀芬. 宫腔镜手术联合孕激素对多发性子宫内膜息肉术后复发的影响[J]. 中国妇产科临床杂志, 2017, 18(3): 259-260. https://www.cnki.com.cn/Article/CJFDTOTAL-FKLC201703029.htm
[12]	黄晓晖, 和秀魁, 黄彩彩, 等. VEGF在子宫内膜息肉的表达及口服避孕药对其的下调作用[J]. 国际医药卫生导报, 2018, 24(5): 632-634. doi: 10.3760/cma.j.issn.1007-1245.2018.05.003

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口服避孕药预防宫腔镜子宫内膜息肉切除术后复发的效果观察

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Effect of oral administration of contraceptives on prevention of recurrence after hysteroscopic endometrial polypectomy

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