Effects of mucopolysaccharide polysulfate cream combined with zinc oxide ointment on interferon-γ, interleukin-4 and interleukin-10 in infants with eczema
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摘要:目的 探讨采用多磺酸粘多糖乳膏联合氧化锌软膏对湿疹婴儿干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)及白细胞介素-10(IL-10)水平的影响。方法 选取湿疹婴儿80例, 随机分为对照组、观察组，各40例。对照组采用多磺酸粘多糖乳膏治疗，观察组采用多磺酸粘多糖乳膏联合氧化锌软膏治疗。比较2组患儿用药前后IFN-γ、IL-4及IL-10水平，并对比2组的临床疗效和患儿的临床症状评分情况。结果 用药前, 2组患儿IFN-γ、IL-4及IL-10水平无显著差异(P>0.05); 治疗后，观察组患儿IFN-γ水平显著高于对照组, IL-4及IL-10水平显著低于对照组(P < 0.05)。观察组的治疗总有效率显著高于对照组(P < 0.05), 临床症状评分显著优于对照组(P < 0.05)。结论 采用多磺酸粘多糖乳膏联合氧化锌软膏治疗湿疹婴儿效果十分理想，可有效改善患儿的细胞因子水平，并使患儿的临床症状得以明显改善。Abstract:Objective To investigate the effect of mucopolysaccharide polysulfate cream combined with zinc oxide ointment on the levels of interferon-γ (IFN-γ), interleukin-4 (IL-4) and interleukin-10 (IL-10) in eczema infants.Methods A total of 80 infants with eczema admitted to our hospital were randomly divided into control group (n=40) and observation group (n=40). The control group was treated with mucopolysaccharide polysulfate cream, while the observation group was treated with mucopolysaccharide polysulfate cream combined with zinc oxide ointment. The levels of IFN-γ, IL-4 and IL-10 before and after treatment were compared between the two groups. The clinical efficacy and the score of clinical symptoms were compared between the two groups.Results There was no significant difference in the levels of IFN-γ, IL-4 and IL-10 between the two groups before treatment (P>0.05). After treatment, the level of IFN-γ in the observation group was higher and levels of IL-4 and IL-10 in the observation group were significantly lower than those in the control group (P < 0.05). The total effective rate in the observation group was higher, and clinical symptom scores in the observation group was better than that in the control group (P < 0.05).Conclusion The therapeutic effect of two ointments for infants with eczema is ideal, which can effectively improve the level of cytokines and the clinical symptoms of children.
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表 1 2组患儿IFN-γ、IL-4及IL-10水平比较(x±s)
组别 IFN-γ/(ng/mL) IL-4/(pg/mL) IL-10/(ng/L) 治疗前 治疗后 治疗前 治疗后 治疗前 治疗后 对照组(n=40) 44.18±2.13 51.89±0.24* 70.59±0.53 50.28±0.21* 13.70±0.24 10.24±0.46* 观察组(n=40) 44.16±2.11 62.19±0.28*# 70.58±0.54 35.41±0.24*# 13.69±0.25 7.24±0.24*# IFN-γ: 干扰素-γ; IL-4: 白细胞介素-4; IL-10: 白细胞介素-10。与治疗前比较, *P < 0.05; 与对照组比较, #P < 0.05。 
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表 2 2组患儿疗效比较[n(%)]
组别 n 有效 显效 无效 总有效 对照组 40 10(25.00) 20(50.00) 10(25.00) 30(75.00) 观察组 40 25(62.50) 13(32.50) 2(5.00) 38(95.00)* 与对照组比较, *P < 0.05。
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表 3 2组患儿临床症状评分(x±s)
分 时点 对照组(n=40) 观察组(n=40) 治疗前 2.74±0.13 2.73±0.12 治疗后15 d 1.68±0.24 1.38±0.12* 治疗后1个月 1.31±0.12 1.01±0.21* 治疗后2个月 1.04±0.21 0.71±0.12* 与对照组比较, *P < 0.05。
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