Value of ultrasonography in the diagnosis of benign and malignant axillary lymph nodes in breast cancer
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摘要:目的 研究超声造影对于乳腺癌腋窝良恶性淋巴结的诊断价值。方法 选取本院乳腺中心收治的单侧乳腺癌合并同侧腋窝淋巴结肿大患者74例,根据术后病理诊断结果将腋窝淋巴结患者分为对照组和观察组。对照组38例为良性淋巴结,观察组36例为转移性淋巴结,对2组腋窝淋巴结均行常规超声检查和超声造影检查。以病理诊断为金标准,分析常规超声和超声造影的诊断价值,并比较灵敏度、特异度、诊断符合率。结果 对照组淋巴结的长短径比值(L/S) < 2、内部回声不均匀和宽阔型皮质的发生率均显著低于观察组(P < 0.05); 2组血流分布、增强模式差异显著(P < 0.05); 2组的血流阻力指数差异无统计学意义(P>0.05); 对照组造影强化时间显著短于观察组(P < 0.05); 超声造影的诊断灵敏度和特异度均高于常规超声,但2组差异无统计学意义(P>0.05); 超声造影的诊断符合率显著高于常规超声(P < 0.05)。结论 超声造影无创、安全性高,能够弥补常规超声在诊断中的不足,且在诊断乳腺癌腋窝良恶性淋巴结中灵敏度、特异度和诊断符合率均较高。Abstract:Objective To study the value of ultrasonography in the diagnosis of benign and malignant lymph nodes in breast cancer.Methods A total of 74 patients with unilateral breast cancer and ipsilateral axillary lymphadenopathy admitted to our hospital were selected. According to the pathological diagnosis, the axillary lymph nodes were divided into control group(38 patients with benign lymph nodes) and observation group(36 patients with metastatic lymph nodes). Routine ultrasound examination and contrast-enhanced ultrasonography were performed on both axillary lymph nodes. Taking pathological diagnosis as the gold standard, the diagnostic value of conventional ultrasound and contrast-enhanced ultrasound was analyzed, the sensitivity, specificity and diagnostic coincidence rate of the two groups were compared.Results The incidence of length diameter to short diameter ratio (L/S) < 2, internal echo unevenness and broad cortex in the control group were significantly lower than those in the observation group (P < 0.05). The blood flow distribution and enhancement pattern of two groups showed significant difference (P < 0.05). There was no significant difference in blood flow resistance index between the control group and the observation group (P>0.05). The contrast enhancement time of the control group was significantly shorter than that of the observation group (P < 0.05). The diagnostic sensitivity and specificity of contrast-enhanced ultrasound were higher than conventional ultrasound, but the differences between the two groups showed no statistically significant (P>0.05). The diagnostic coincidence rate of contrast-enhanced ultrasound was significantly higher than that of conventional ultrasound (P < 0.05).Conclusion Contrast-enhanced ultrasonography is a non-invasive and safe therapy, which can make up the deficiency of conventional ultrasound in diagnosis, and has higher sensitivity, specificity and diagnostic coincidence rate in the diagnosis of benign and malignant axillary lymph nodes of breast cancer.
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表 1 2组患者的超声检查结果分析(x±s)[n(%)]
组别 n L/S<2 内部回声不均匀 宽阔型皮质 血流分布 血流阻力指数 门型 边缘型 混合型 对照组 38 4(10.53) 5(10.53) 2(5.26) 30(78.95) 3(7.89) 5(13.16) 0.51±0.07 观察组 36 28(77.78)* 24(63.16)* 32(88.89)* 7(18.42)* 20(52.63)* 9(23.68)* 0.53±0.06 与对照组比较, *P < 0.05。 表 2 2组腋窝淋巴结的超声造影结果分析(x±s)[n(%)]
组别 n 造影强化时间/ms 增强模式 周边增强 局部增强 整体增强 对照组 38 179.54±44.32 2(5.26) 1(2.63) 35(92.11) 观察组 36 364.82±62.85* 26(72.22) 8(22.22) 2(5.56) 与对照组比较, *P < 0.05。 -
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