益生菌联合康复新液治疗活动期轻中度溃疡性结肠炎的效果观察

陈莉

doi:10.7619/jcmp.201912027

益生菌联合康复新液治疗活动期轻中度溃疡性结肠炎的效果观察

陈莉

江苏省张家港市第一人民医院, 江苏张家港, 215600

详细信息

中图分类号: R514.6
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出版历程
- 收稿日期: 2019-03-22
- 录用日期: 2019-05-09
- 网络出版日期: 2021-02-22
- 发布日期: 2019-06-27

Effect observation of probiotics combined with Kangfuxin solution on treatment of patients with mild to moderate ulcerative colitis in active stage

CHEN Li

Zhangjiagang First People′s Hospital, Zhangjiagang, Jiangsu, 215600

摘要

摘要:
目的探讨益生菌联合康复新液治疗活动期轻中度溃疡性结肠炎的效果。
方法选取64例活动期轻中度溃疡性结肠炎患者，随机分为观察组与对照组。2组均给予常规治疗，对照组在此基础上采用双歧杆菌三联活菌肠胶囊治疗，观察组采用双歧杆菌三联活菌肠胶囊联合康复新液保留灌肠治疗，比较2组患者治疗效果。
结果观察组总有效率为93.75%, 显著高于对照组的81.25%(P < 0.05)。治疗后，观察组中医证候评分均显著低于对照组(P < 0.05)。治疗后, 2组血清C反应蛋白(CRP)、血沉(ESR)、血清降钙素原(PCT)、纤维蛋白原(FIB)、D-二聚体(D-D)指标均较治疗前显著改善(P < 0.05), 且观察组显著优于对照组(P < 0.05)。观察组不良反应发生率为15.63%, 对照组为18.75%, 差异无统计学意义(P>0.05)。
结论对活动期轻中度溃疡性结肠炎患者应用益生菌联合康复新液治疗，可有效缓解患者临床症状，改善患者血清学指标水平。
- 溃疡性结肠炎 /
- 活动期 /
- 益生菌 /
- 康复新液
Abstract:
Objective To investigate the effect of probiotics combined with Kangfuxin liquid in the treatment of patients with mild to moderate ulcerative colitis in active stage.
Methods A total of 64 patients with mild to moderate active ulcerative colitis were randomly divided into observation group and control group. Both groups were treated with conventional therapy, the control group was treated with bifidobacterium triple viable enteral capsule, while the observation group was treated with bifidobacterium triple viable enteral capsule combined with Kangfuxin liquid for retention enema. The therapeutic effect of the two groups was compared.
Results The total effective rate was 93.75% in the observation group, which was significantly higher than 81.25% in the control group (P < 0.05). After treatment, the scores of TCM syndromes in the observation group were significantly lower than those in the control group (P < 0.05). After treatment, the serum C reactive protein (CRP), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), fibrinogen (FIB), D-dimer (D-D) in both groups significantly improved when compared with those before treatment (P < 0.05), and the indexes in the observation group were significantly better than those in the control group (P < 0.05). The incidence rate of adverse reactions was 15.63% in the observation group and 18.75% in the control group, and there was no significant difference between two groups (P>0.05).
Conclusion Probiotics combined with Kangfuxin solution can effectively relieve the clinical symptoms and improve the level of serological indicators in patients with mild to moderate ulcerative colitis in active stage.
- ulcerative colitis /
- active stage /
- probiotics /
- Kangfuxin solution

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表 1 2组临床疗效对比[n(%)]

组别	显效	有效	无效	总有效
观察组(n=32)	21(65.63)	9(28.13)	2(6.25)	30(93.75)^*
对照组(n=32)	14(43.75)	12(37.50)	6(18.75)	26(81.25)
与对照组比较, *P < 0.05。

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表 2 2组治疗后中医证候评分对比(x±s) 分

中医证候	观察组(n=32)	对照组(n=32)
腹泻	0.72±0.28^*	1.86±0.73
腹痛	0.81±0.22^*	1.26±0.71
黏液脓血便	0.52±0.22^*	1.82±0.89
里急后重	0.57±0.21^*	1.86±0.84
与对照组比较, *P < 0.05。

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表 3 2组治疗前后相关指标对比(x±s)

组别	时点	CRP/(mg/L)	ESR/(mm/h)	PCT/(ng/mL)	FIB/(g/L)	D-D/(μg/L)
观察组(n=32)	治疗前	32.31±12.66	28.19±9.53	1.26±0.37	4.96±0.57	374.83±93.16
	治疗后	12.46±5.37^*#	9.07±3.44^*#	0.53±0.14^*#	3.18±0.32^*#	228.37±64.52^*#
对照组(n=32)	治疗前	31.95±12.72	27.66±9.81	1.28±0.36	4.97±0.53	376.54±92.86
	治疗后	18.53±9.14^*	16.24±6.83^*	0.82±0.23^*	4.17±0.44^*	334.64±78.34^*
CRP: C反应蛋白; ESR: 血沉; PCT: 血清降钙素原; FIB: 纤维蛋白原; D-D: D-二聚体。与治疗前比较, *P < 0.05; 与对照组比较, #P < 0.05。

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表 4 2组不良反应情况比较

组别	头痛	恶心	轻度头晕	合计/%
观察组(n=32)	2	2	1	15.63
对照组(n=32)	1	4	1	18.75

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益生菌联合康复新液治疗活动期轻中度溃疡性结肠炎的效果观察

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Effect observation of probiotics combined with Kangfuxin solution on treatment of patients with mild to moderate ulcerative colitis in active stage

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