Clinical significance of transaminase detection in infants with bronchiolitis infected by respiratory syncytial virus
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摘要:目的 探讨转氨酶[谷丙转氨酶(ALT)、谷草转氨酶(AST)]检测在婴幼儿呼吸道合胞病毒(RSV)感染的毛细支气管炎患儿中的临床意义。方法 对58例RSV毛细支气管炎、197例非RSV毛细支气管炎患儿进行ALT与AST检测，比较2组患儿转氨酶水平对疾病严重程度的影响。结果 RSV组与非RSV组ALT、AST水平无显著差异(P>0.05)，但RSV组转氨酶升高患儿例数显著多于非RSV组(P < 0.05)。RSV组中转氨酶升高的患儿使用呼吸机的例数以及住院时间均显著多于、长于转氨酶正常的RSV患儿(P < 0.05)。结论 转氨酶的升高与RSV毛细支气管炎患儿疾病的严重程度有相关性。Abstract:Objective To explore the clinical significance of transaminase[alanine aminotransferase (ALT) and aspartate aminotransferase (AST)]detection in infants with bronchiolitis infected by respiratory syncytial virus (RSV).Methods The levels of ALT and AST were detected in 58 infants with RSV bronchiolitis and 197 infants with non-RSV bronchiolitis, and the effect of transaminase level on disease severity were compared between the two groups.Results There were no significant differences in levels of ALT and AST between the RSV group and the non-RSV group (P>0.05), but the proportion of infants with increased transaminase in the RSV group was significantly higher than that in the non-RSV group (P < 0.05). In the RSV group, the cases with ventilator and hospital stay in infants with increased transaminase were significantly higher and longer than those in the infants with normal transaminase (P < 0.05).Conclusion Increased transaminase level is associated with the severity of RSV bronchiolitis in infants.
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Keywords:
- transaminase /
- respiratory syncytial virus /
- bronchiolitis /
- infants
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表 1 RSV组与非RSV组临床资料的比较(x±s)
组别 n 月龄/月 性别 ALT/(U/L) AST/(U/L) ALT/AST 住院时间/d 男 女 升高 正常 RSV组 58 13.58±6.76 32 26 37.78±32.76 37.93±39.50 16 42 8.50±2.73 非RSV组 197 12.35±6.94 142 113 30.83±25.19 30.42±20.72* 29* 168 8.70±3.16 ALT: 谷丙转氨酶; AST: 谷草转氨酶。ALT/AST表示ALT、AST中至少有1项升高。与RSV组比较, *P < 0.05。 
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