Huang Z K, Luo Q, Guo Y, et al. Mycobacterium tuberculosis-induced polarization of human macrophage orchestrates the formation and development of tuberculous granulomas in vitro[J]. PLoS One, 2015, 10(6): e0129744. doi: 10.1371/journal.pone.0129744

Barros M H, Hauck F, Dreyer J H, et al. Macrophage polarisation: an immunohistochemical approach for identifying M1 and M2 macrophages[J]. PLoS One, 2013, 8(11): e80908. doi: 10.1371/journal.pone.0080908

Britton W J, Lockwood D N. Leprosy[J]. Lancet, 2004, 363(9416): 1209-1219. doi: 10.1016/S0140-6736(04)15952-7

Little D, Khanolkar-Young S, Coulthart A, et al. Immunohistochemical analysis of cellular infiltrate and gamma interferon, interleukin-12, and inducible nitric oxide synthase expression in leprosy type 1 (reversal) reactions before and during prednisolone treatment[J]. Infect Immun, 2001, 69(5): 3413-3417. doi: 10.1128/IAI.69.5.3413-3417.2001

Sieling P A, Wang X H, Gately M K, et al. IL-12 regulates T helper type 1 cytokine responses in human infectious disease[J]. J Immunol, 1994, 153(8): 3639-3647. http://europepmc.org/abstract/MED/7930584

Jullien D, Sieling P A, Uyemura K, et al. IL-15, an immunomodulator of T cell responses in intracellular infection[J]. J Immunol, 1997, 158(2): 800-806. http://thorax.bmj.com/cgi/ijlink?linkType=ABST&journalCode=jimmunol&resid=158/2/800

Kim J, Uyemura K, Van Dyke M K, et al. A role for IL-12 receptor expression and signal transduction in host defense in leprosy[J]. J Immunol, 2001, 167(2): 779-786. doi: 10.4049/jimmunol.167.2.779

Yamamura M, Wang X H, Ohmen J D, et al. Cytokine patterns of immunologically mediated tissue damage[J]. J Immunol, 1992, 149(4): 1470-1475. http://jid.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=jimmunol&resid=149/4/1470

Marino S, Cilfone N A, Mattila J T, et al. Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection[J]. Infect Immun, 2015, 83(1): 324-338. doi: 10.1128/IAI.02494-14

Baughman R P, Lower E E, du Bois R M. Sarcoidosis[J]. Lancet, 2003, 361(9363): 1111-1118. doi: 10.1016/S0140-6736(03)12888-7

Morimoto T, Azuma A, Abe S, et al. Epidemiology of sarcoidosis in Japan[J]. Eur Respir J, 2008, 31(2): 372-379. doi: 10.1183/09031936.00075307

Sanchez M, Haimovic A, Prystowsky S. Sarcoidosis[J]. Dermatol Clin, 2015, 33(3): 389-416. doi: 10.1016/j.det.2015.03.006

Ina Y, Takada K, Yamamoto M, et al. HLA and sarcoidosis in the Japanese[J]. Chest, 1989, 95(6): 1257-1261. doi: 10.1378/chest.95.6.1257

Lenhart K, Kolek V, Bártova A. HLA antigens associated with sarcoidosis[J]. Dis Markers, 1990, 8(1): 23-29. http://www.ncbi.nlm.nih.gov/pubmed/2311346

Kunikane H, Abe S, Tsuneta Y, et al. Role of HLA-DR antigens in Japanese patients with sarcoidosis[J]. Am Rev Respir Dis, 1987, 135(3): 688-691. http://www.ncbi.nlm.nih.gov/pubmed/3826893

Nowack D, Goebel K M. Genetic aspects of sarcoidosis. Class II histocompatibility antigens and a family study[J]. Arch Intern Med, 1987, 147(3): 481-483. doi: 10.1001/archinte.1987.00370030085016

Ishihara M, Ohno S. Genetic influences on sarcoidosis[J]. Eye (Lond), 1997, 11(Pt 2): 155-161. http://www.ncbi.nlm.nih.gov/pubmed/9349405/

Barnard J, Rose C, Newman L, et al. Job and industry classifications associated with sarcoidosis in A Case-Control Etiologic Study of Sarcoidosis (ACCESS)[J]. J Occup Environ Med, 2005, 47(3): 226-234. doi: 10.1097/01.jom.0000155711.88781.91

Judson M A, Marchell R M, Mascelli M, et al. Molecular profiling and gene expression analysis in cutaneous sarcoidosis: the role of interleukin-12, interleukin-23, and the T-helper 17 pathway[J]. J Am Acad Dermatol, 2012, 66(6): 901-910. doi: 10.1016/j.jaad.2011.06.017

Song Z M, Marzilli L, Greenlee B M, et al. Mycobacterial catalase-peroxidase is a tissue antigen and target of the adaptive immune response in systemic sarcoidosis[J]. J Exp Med, 2005, 201(5): 755-767. doi: 10.1084/jem.20040429

Brownell I, Ramírez-Valle F, Sanchez M, et al. Evidence for mycobacteria in sarcoidosis[J]. Am J Respir Cell Mol Biol, 2011, 45(5): 899-905. doi: 10.1165/rcmb.2010-0433TR

Oswald-Richter K A, Beachboard D C, Seeley E H, et al. Dual analysis for mycobacteria and propionibacteria in sarcoidosis BAL[J]. J Clin Immunol, 2012, 32(5): 1129-1140. doi: 10.1007/s10875-012-9700-5

Eishi Y. Etiologic aspect of sarcoidosis as an allergic endogenous infection caused by Propionibacterium acnes[J]. Biomed Res Int, 2013, 2013: 935289. http://europepmc.org/abstract/med/23844371

Eishi Y. Etiologic link between sarcoidosis and Propionibacterium acnes[J]. Respir Investig, 2013, 51(2): 56-68. doi: 10.1016/j.resinv.2013.01.001

Homma J Y, Abe C, Chosa H, et al. Bacteriological investigation on biopsy specimens from patients with sarcoidosis[J]. Jpn J Exp Med, 1978, 48(3): 251-255. http://europepmc.org/abstract/MED/713130

Mitsuoka T, Benno Y, Homma J Y, et al. Characterization of Propionibacterium acnes isolated from biopsy specimens obtained from patients with sarcoidosis[J]. Jpn J Exp Med, 1978, 48(3): 275-277. http://europepmc.org/abstract/MED/713132

Ishige I, Usui Y, Takemura T, et al. Quantitative PCR of mycobacterial and propionibacterial DNA in lymph nodes of Japanese patients with sarcoidosis[J]. The Lancet, 1999, 354(9173): 120-123. doi: 10.1016/S0140-6736(98)12310-3

Keimig E L. Granuloma annulare[J]. Dermatol Clin, 2015, 33(3): 315-329. doi: 10.1016/j.det.2015.03.001

Thornsberry L A, English J C rd. Etiology, diagnosis, and therapeutic management of granuloma annulare: an update[J]. Am J Clin Dermatol, 2013, 14(4): 279-290. doi: 10.1007/s40257-013-0029-5

Yoon N Y, Lee N R, Choi E H. Generalized granuloma annulare after bacillus Calmette-Guérin vaccination, clinically resembling papular tuberculid[J]. J Dermatol, 2014, 41(1): 109-111. doi: 10.1111/1346-8138.12293

Agrawal A K, Kammen B F, Guo H, et al. An unusual presentation of subcutaneous granuloma annulare in association with juvenile-onset diabetes: case report and literature review[J]. Pediatr Dermatol, 2012, 29(2): 202-205. doi: 10.1111/j.1525-1470.2011.01638.x

Toro J R, Chu P, Yen T S, et al. Granuloma annulare and human immunodeficiency virus infection[J]. Arch Dermatol, 1999, 135(11): 1341-1346. http://new.med.wanfangdata.com.cn/Paper/Detail?id=PeriodicalPaper_JJ0210327794

Maschio M, Marigliano M, Sabbion A, et al. A rare case of granuloma annulare in a 5-year-old child with type 1 diabetes and autoimmune thyroiditis[J]. The American Journal of Dermatopathology, 2013, 35(3): 385-387. doi: 10.1097/DAD.0b013e318272f6c6

Barksdale S K, Perniciaro C, Halling K C, et al. Granuloma annulare in patients with malignant lymphoma: clinicopathologic study of thirteen new cases[J]. J Am Acad Dermatol, 1994, 31(1): 42-48. doi: 10.1016/S0190-9622(94)70133-4

Dadban A, Slama B, Azzedine A, et al. Widespread granuloma annulare and Hodgkin′s disease[J]. Clin Exp Dermatol, 2008, 33(4): 465-468. doi: 10.1111/j.1365-2230.2008.02730.x

Haim S, Friedman-Birnbaum R, Shafrir A. Generalized granuloma annulare: relationship to diabetes mellitus as revealed in 8 cases[J]. Br J Dermatol, 1970, 83(2): 302-305. doi: 10.1111/j.1365-2133.1970.tb15704.x

Haim S, Friedman-Birnbaum R, Shafrir A. Granuloma annulare and diabetes[J]. Harefuah, 1970, 78(9): 433-435. http://www.ncbi.nlm.nih.gov/pubmed/5495798

Zanolli M D, Powell B L, McCalmont T, et al. Granuloma annulare and disseminated herpes zoster[J]. Int J Dermatol, 1992, 31(1): 55-57. doi: 10.1111/j.1365-4362.1992.tb03523.x

Friedman S J, Fox B J, Albert H L. Granuloma annulare arising in herpes zoster scars. Report of two cases and review of the literature[J]. J Am Acad Dermatol, 1986, 14(5 Pt 1): 764-770. http://www.sciencedirect.com/science/article/pii/S0190962286700911

Singh S K, Manchanda K, Bhayana A A, et al. Allopurinol induced granuloma annulare in a patient of lepromatous leprosy[J]. J Pharmacol Pharmacother, 2013, 4(2): 152-154. doi: 10.4103/0976-500X.110915

Brechtel B, Kolde G. Granuloma annulare disseminatum as a rare side effect of allopurinol[J]. Hautarzt, 1996, 47(2): 143-143. doi: 10.1007/s001050050395

Lagier L, Dunoyer E, Estève E. Topiramate: a new inductor of granuloma annulare[J]. Ann Dermatol Venereol, 2011, 138(2): 141-143. doi: 10.1016/j.annder.2010.11.014

Ahmad U, Li X, Sodeman T, et al. Hepatitis C virus treatment with pegylated interferon-alfa therapy leading to generalized interstitial granuloma annulare and review of the literature[J]. Am J Ther, 2013, 20(5): 585-587. doi: 10.1097/MJT.0b013e318209e049

Kluger N, Moguelet P, Chaslin-Ferbus D, et al. Generalized interstitial granuloma annulare induced by pegylated interferon-alpha[J]. Dermatology (Basel), 2006, 213(3): 248-249. doi: 10.1159/000095048

Viguier M, Richette P, Bachelez H, et al. Paradoxical cutaneous manifestations during anti-TNF-alpha therapy[J]. Ann Dermatol Venereol, 2010, 137(1): 64-71, 78-79. doi: 10.1016/j.annder.2009.10.003

Fayyazi A, Schweyer S, Eichmeyer B, et al. Expression of IFNgamma, coexpression of TNFalpha and matrix metalloproteinases and apoptosis of T lymphocytes and macrophages in granuloma annulare[J]. Arch Dermatol Res, 2000, 292(8): 384-390. doi: 10.1007/s004030000150

Voulgari P V, Markatseli T E, Exarchou S A, et al. Granuloma annulare induced by anti-tumour necrosis factor therapy[J]. Ann Rheum Dis, 2008, 67(4): 567-570. doi: 10.1136/ard.2007.075663

Cassone G, Tumiati B. Granuloma annulare as a possible new adverse effect of topiramate[J]. Int J Dermatol, 2014, 53(2): 259-261. doi: 10.1111/ijd.12189

Mocan T, Matea C, Tabaran F, et al. In vitro administration of gold nanoparticles functionalized with MUC-1 protein fragment generates anticancer vaccine response via macrophage activation and polarization mechanism[J]. J Cancer, 2015, 6(6): 583-592. doi: 10.7150/jca.11567

Min M S, Lebwohl M. Treatment of recalcitrant granuloma annulare (GA) with adalimumab: A single-center, observational study[J]. J Am Acad Dermatol, 2016, 74(1): 127-133. doi: 10.1016/j.jaad.2015.09.015

Murdaca G, Colombo B M, Barabino G, et al. Anti-tumor necrosis factor-α treatment with infliximab for disseminated granuloma annulare[J]. Am J Clin Dermatol, 2010, 11(6): 437-439. doi: 10.2165/11311040-000000000-00000

Shupack J, Siu K. Resolving granuloma annulare with etanercept[J]. Arch Dermatol, 2006, 142(3): 394-395. http://www.ncbi.nlm.nih.gov/pubmed/16549725

Jiang D H, Liang J R, Fan J, et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan[J]. Nat Med, 2005, 11(11): 1173-1179. doi: 10.1038/nm1315

Chavan R N, Lehman J S, Flotte T J. Dendritic cells are prominent in granuloma annulare[J]. J Am Acad Dermatol, 2014, 71(5): 1020-1022. doi: 10.1016/j.jaad.2014.06.020

Kolovics J, Mattes L P, Andersen K E, et al. Squamous cell carcinoma developing in necrobiosis lipoidica in a diabetic patient[J]. Ugeskr Laeg, 2015, 177(38): V01150054. http://www.ncbi.nlm.nih.gov/pubmed/26376417

Souza F H, Ribeiro C F, Pereira M A, et al. Simultaneous occurrence of ulcerated necrobiosis lipoidica and granuloma annulare in a patient: case report[J]. An Bras Dermatol, 2011, 86(5): 1007-1010. doi: 10.1590/S0365-05962011000500023

Sizmaz S, Pelit A, Bolat F, et al. Periorbital necrobiosis lipoidica diabeticorum: case report[J]. Int Ophthalmol, 2008, 28(4): 307-309. doi: 10.1007/s10792-007-9133-y

Alonso M L, Riós J C, González-Beato M J, et al. Necrobiosis lipoidica of the glans penis[J]. Acta Derm Venereol, 2011, 91(1): 105-106. doi: 10.2340/00015555-0993

Töröcsik D, Bárdos H, Hatalyák Z, et al. Detection of factor XIII-A is a valuable tool for distinguishing dendritic cells and tissue macrophages in granuloma annulare and necrobiosis lipoidica[J]. J Eur Acad Dermatol Venereol, 2014, 28(8): 1087-1096. doi: 10.1111/jdv.12290

Jun A S, Takenaka H, Hirakawa S, et al. Topical simvastatin accelerates wound healing in diabetes by enhancing angiogenesis and lymphangiogenesis[J]. Am J Pathol, 2012, 181(6): 2217-2224. doi: 10.1016/j.ajpath.2012.08.023

Bauer M F, Hirsch P, Bullock W K, et al. Necrobiosis lipoidica diabeticorum. a cutaneous manifestation of diabetic microangiopathy[J]. Arch Dermatol, 1964, 90: 558-566. doi: 10.1001/archderm.1964.01600060024004

Holland C, Givens V, Smoller B R. Expression of the human erythrocyte glucose transporter Glut-1 in areas of sclerotic collagen in necrobiosis lipoidica[J]. J Cutan Pathol, 2001, 28(6): 287-290. doi: 10.1034/j.1600-0560.2001.028006287.x

Muller S A, Winkelmann R K. Necrobiosis lipoidica diabeticorum histopathologic study of 98 cases[J]. Arch Dermatol, 1966, 94(1): 1-10. doi: 10.1001/archderm.1966.01600250007001

Muller S A, Winkelmann R K. Necrobiosis lipoidica diabeticorum. A clinical and pathological investigation of 171 cases[J]. Arch Dermatol, 1966, 93(3): 272-281. doi: 10.1001/archderm.1966.01600210008002

O′Toole E A, Kennedy U, Nolan J J, et al. Necrobiosis lipoidica: only a minority of patients have diabetes mellitus[J]. Br J Dermatol, 1999, 140(2): 283-286. doi: 10.1046/j.1365-2133.1999.02663.x