超保守RNA uc. 189在大肠癌组织中的表达及临床病理意义

邓慧; 李鑫雨; 吴燕丹; 王成海

doi:10.7619/jcmp.201909002

超保守RNA uc. 189在大肠癌组织中的表达及临床病理意义

邓慧^{1, 2},
李鑫雨¹,
吴燕丹¹,
王成海^{1, 3,}

1.
扬州大学医学院(转化医学研究院), 江苏扬州, 225009
2.
扬州大学医学院附属扬州洪泉医院病理科, 江苏江都, 225200
3.
江苏省中西医结合老年病防治重点实验室, 江苏扬州, 225009

基金项目:

江苏省扬州市重点研究项目-社会发展计划 YZ2016065

详细信息

作者简介:
王成海, E-mail: chwang@yzu.edu.cn

中图分类号: R735.3
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- 文章访问数: 261
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出版历程
- 收稿日期: 2019-02-12
- 录用日期: 2019-03-19
- 网络出版日期: 2020-12-21
- 发布日期: 2019-05-14

Expression of super conservative RNA uc.189 in colorectal cancer and its clinicpathological significance

DENG Hui^{1, 2},
LI Xinyu¹,
WU Yandan¹,
WANG Chenghai^{1, 3,}

1.
Institute of Translational Medicine of Medical College of Yangzhou University, Yangzhou, Jiangsu, 225009
2.
Department of Pathology, Yangzhou Hongquan Hospital Affiliated to Medical College of Yangzhou University, Jiangdu, Jiangsu, 225200
3.
Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Control of Geriatric Diseases, Yangzhou, Jiangsu, 225009

摘要

摘要:
目的探讨超保守RNA uc. 189在大肠癌组织中的表达及临床意义。
方法从130例大肠癌组织及对应的癌旁正常组织中提取RNA, 应用实时荧光定量PCR(qRT-PCR)技术检测uc. 189的RNA表达情况, 并分析其与大肠癌患者病理参数的关系。
结果 uc.189在大肠癌组织中的RNA表达水平显著高于相应的癌旁正常组织(P < 0.05), 其高表达与大肠癌分化程度、淋巴结转移和TNM分期密切相关。
结论 uc.189与大肠癌的发生、发展密切相关。
- 超保守RNA /
- uc.189 /
- 大肠癌 /
- 病理参数
Abstract:
Objective To investigate the expression of super conservative RNA uc.189 in colorectal cancer and its clinical significance.
Methods Total RNA was extracted from 130 pairs of colorectal cancer tissues and adjacent normal colorectal tissues. The RNA expression of uc.189 was detected by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), and the relationship between uc.189 expression and clinic pathological parameters was analyzed.
Results The RNA expression of uc.189 was significantly higher in colorectal cancer tissues than that in adjacent normal tissues (P < 0.05). The high expression of uc.189 in colorectal cancer was associated with the pathological grading, lymphatic metastasis and TNM staging (P < 0.05).
Conclusion The uc.189 is associated with the occurrence and development of colorectal cancer.
- super conservative RNA /
- uc.189 /
- colorectal cancer /
- pathological parameters

HTML全文

图 1 uc.189在大肠癌中的相对表达

与癌旁正常肠组织比较, *P < 0.05

下载: 全尺寸图片幻灯片

表 1 大肠癌组织中uc.189表达与临床病理特征的相关性

临床病理特征		uc.189高表达(n=112)	uc.189正常或低表达(n=18)	χ²	P
年龄	< 55岁	49	8	0.003	0.956
	≥55岁	63	10
性别	男	66	13	1.150	0.284
	女	46	5
肿瘤大小	< 5 cm	58	9	0.020	0.888
	≥5 cm	54	9
浸润深度	黏膜层+黏膜下层	31	9	2.076	0.150
	肌层+外膜	81	9
淋巴结转移	阴性	23	13	20.690	0.000
	阳性	89	5
远处转移	阴性	76	14	0.716	0.397
	阳性	36	4
肿瘤TNM分期	Ⅰ+Ⅱ	39	12	6.597	0.010
	Ⅲ+Ⅳ	72	6
分化程度	高	32	11	7.418	0.006
	中、低	80	7

下载: 导出CSV

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超保守RNA uc. 189在大肠癌组织中的表达及临床病理意义

作者简介: 王成海, E-mail: chwang@yzu.edu.cn

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出版历程

Expression of super conservative RNA uc.189 in colorectal cancer and its clinicpathological significance

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出版历程

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作者简介:
王成海, E-mail: chwang@yzu.edu.cn