Effect of early sedative on prevention of febrile convulsion epilepsy in children
-
摘要:目的 探讨早期应用镇静剂对小儿热性惊厥癫痫的预防效果。方法 选择在本院进行治疗的小儿热性惊厥癫痫患儿146例为研究对象，按照随机数表法将其随机分为对照组和研究组，每组73例。对照组使用对症降温等常规治疗，研究组早期使用镇静剂进行治疗，6个月后，比较2组患儿的临床症状以及预防效果。结果 治疗后，研究组癫痫、脑损伤、智力低下的发生率显著低于对照组(P < 0.05); 研究组治愈率显著高于对照组，复发率显著低于对照组(P < 0.05)。结论 应用镇静剂对早期小儿热性惊厥癫痫病患儿进行治疗效果明显，可缓解病症，有效预防热性惊厥引起癫痫等并发症，降低复发率。Abstract:Objective To explore the effect of early sedative in prevention of febrile convulsion epilepsy in children.Methods A total of 146children with febrile convulsion epilepsy who were treated in our hospital were selected as the researchobjects. According to the random number table method, they were randomly divided into control group and research group, with 73 cases in each group. The control group was treated with routine treatment such as symptomatic cooling, while the study group was treated with sedatives at the early stage. After 6 months, the clinical symptoms and preventive effects of the two groups were compared.Results After treatment, the incidences of epilepsy, brain injury and mental retardation in the study group were significantly lower than that in the control group (P < 0.05), and the cure rate in the study group was significantly higher, and recurrence rate was significantly lower than that of the control group(P < 0.05).Conclusion Sedatives are effective in the treatment of early febrile convulsions and epilepsy in children. It can alleviate the symptoms, effectively prevent the seizures caused by febrile convulsions and other complications, and reduce the recurrence rate.
-
Keywords:
- febrile convulsions /
- epilepsy /
- sedatives /
- prevention
-
-
表 1 2组患儿治疗效果比较[n(%)]
组别 n 癫痫 脑损伤 智力低下 治愈 对照组 73 11(15.07) 7(9.59) 3(4.11) 52(71.23) 研究组 73 2(2.74)* 2(2.74)* 1(1.37)* 68(93.15)* 与对照组比较, *P < 0.05。 
下载: 导出CSV
表 2 2组患儿治疗后复发情况比较(x±s)[n(%)]
组别 n 复发次数/次 复发 1次 2次 3次及以上 平均次数 对照组 73 15 7 4 1.92±0.97 26(35.62) 研究组 73 2* 1* 0* 0.41±0.11* 3(4.11)* 与对照组比较, *P < 0.05。
下载: 导出CSV
-
[1] 史晓玲. 小儿热性惊厥致癫痫早期应用镇静剂预防效果研究[J]. 中国地方病防治杂志, 2017, 32(8): 941-941, 943. https://www.cnki.com.cn/Article/CJFDTOTAL-DYBF201708063.htm [2] 吴亚臻, 李琴. 中西医结合治疗小儿高热惊厥的临床疗效[J]. 中国现代医学杂志, 2018, 28(16): 77-81. doi: 10.3969/j.issn.1005-8982.2018.16.016 [3] 谢静, 谢明峰, 何星星. 热性惊厥复发患儿体质类型分布及其与免疫功能关系的研究[J]. 南京中医药大学学报, 2018, 34(4): 344-347. https://www.cnki.com.cn/Article/CJFDTOTAL-NJZY201804006.htm [4] 黄春玲, 曹广娜, 童笑梅. 新生儿惊厥2例临床及基因分析[J]. 临床儿科杂志, 2018, 36(9): 666-669. doi: 10.3969/j.issn.1000-3606.2018.09.005 [5] 姜春颖, 滕紫藤, 王丹, 等. 儿童复杂性热性惊厥285例多因素临床分析[J]. 中国实用儿科杂志, 2018, 33(10): 805-808. [6] 向魏坪, 姚玲, 张岩, 等. 血清PCT和CRP预测小儿高热惊厥合并感染的临床价值[J]. 中华医院感染学杂志, 2018, 28(24): 3820-3822, 3826. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201824034.htm [7] 李宁, 陈言钊, 周克英. 儿童热性惊厥临床特征及其变化趋势[J]. 中国当代儿科杂志, 2015, 17(2): 176-179. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ201502017.htm [8] 马思敏, 杨琳, 周文浩. 新生儿惊厥诊断和治疗进展[J]. 中国循证儿科杂志, 2015, 10(2): 126-135. https://www.cnki.com.cn/Article/CJFDTOTAL-XZEK201502014.htm [9] 董娜, 王爱琼. 炎症反应、热性惊厥与继发性癫痫相关性研究进展[J]. 临床儿科杂志, 2015, 33(10): 896-899. doi: 10.3969/j.issn.1000-3606.2015.10.014 [10] 胡家胜, 刘智胜. 儿童重症脑炎惊厥性癫痫持续状态处理[J]. 中国实用儿科杂志, 2015, 30(11): 803-807. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK201511002.htm [11] 杨军, 李水霞, 陈莉娜. 儿童热性惊厥复发危险因素临床分析[J]. 现代预防医学, 2016, 43(24): 4519-4522. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201624027.htm [12] 刘鑫桐, 于盼盼, 孙觊, 等. 癫痫发生过程中免疫学相关机制的研究进展[J]. 中风与神经疾病杂志, 2017, 34(2): 179-182. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFSJ201702029.htm [13] 罗俊, 顾恩华. 非注射类镇静药物用于儿童手术室外镇静的研究进展[J]. 中国药房, 2017, 28(21): 3018-3021. doi: 10.6039/j.issn.1001-0408.2017.21.39 [14] 杜娆, 毛晨梅, 虞勋. 镇静药物在神经外科患儿使用的评估及分析[J]. 中国医院药学杂志, 2017, 37(13): 1263-1267. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYZ201713013.htm [15] 高菡璐, 兰莉, 杨超, 等. 苯巴比妥单一用药治疗农村癫痫患儿疗效分析[J]. 中国现代医学杂志, 2017, 27(15): 74-77. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXDY201715015.htm [16] 杨樟, 徐祖才. 预防性抗癫痫药物治疗研究进展[J]. 重庆医科大学学报, 2016, 41(1): 5-7. https://www.cnki.com.cn/Article/CJFDTOTAL-ZQYK201601002.htm [17] 李学超, 王建忠, 张冬艳, 等. 左乙拉西坦联合丙戊酸钠或地西泮预防小儿热性惊厥反复发作的临床观察[J]. 中国药房, 2016, 27(29): 4106-4109. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYA201629026.htm [18] Adeboye M, Ojuawo A, Adeniyi A, et al. Febrile convulsion among hospitalized children aged six months to five years and its association with haemoglobin electrophoretic pattern[J]. Ethiop J Health Sci, 2015, 25(3): 251-256. http://old.med.wanfangdata.com.cn/viewHTMLEn/PeriodicalPaper_PM26633928.aspx
表(2)
计量
- 文章访问数: 363
- HTML全文浏览量: 250
- PDF下载量: 21
苏公网安备 32100302010246号
