Effect of levocarnitine combined with Yougui Capsule on oligospermia and asthenospermia in male patients
-
摘要:目的 探讨左卡尼汀、右归胶囊联合治疗对男性少精、弱精患者的临床疗效及不良反应。方法 选取80例男性少精、弱精患者，随机分为研究组、对照组各40例，对照组单独采用左卡尼汀治疗，研究组同时联合右归胶囊治疗。治疗3个月后，比较2组总有效率、不良反应发生率、精液质量参数及性激素变化情况。结果 治疗后，研究组的总有效率87.5%、血浆睾酮(T)水平(812.3±130.2) ng/dL、卵泡刺激素(FSH)水平(9.1±3.5) IU/L, 分别显著优于对照组的65.0%、(778.4±113.2) ng/dL、(8.0±2.1) IU/L(P < 0.05); 研究组不良反应发生率为2.5%, 显著低于对照组的20.0%(P < 0.05); 研究组患者的精液质量参数显著优于对照组(P < 0.05)。结论 男性少精、弱精患者采用左卡尼汀、右归胶囊联合治疗，能有效提高性激素水平、精子质量，改善生育功能，不良反应少，疗效安全可靠。Abstract:Objective To analyze the clinical efficacy of levocarnitine combined with Yougui Capsule on oligospermia and asthenospermia in male patients and its adverse effects.Methods Eighty male patients with oligospermia admitted to our hospital were randomly divided into study group and control group, with 40 cases in each group. The control group was treated with levocarnitine alone, and study group was additionally given Yougui Capsule. The total effective rate, incidence of adverse reactions, semen quality parameters and changes of sex hormones were compared between the two groups after 3 months of treatment.Results The total effective rate, plasma testosterone (T) level, and follicle stimulating hormone (FSH) in the study group were 87.50%, (812.3±130.2) ng/dL, and (9.1±3.5) IU/L, respectively, which were superior to 65.0%, (778.4±113.2) ng/dL, (8.0±2.1) IU/L, in the control group(P < 0.05). The incidence rate of adverse reactions in the study group was significantly lower than that of the control group (2.50% vs. 20.00%, P < 0.05). The semen quality parameters of the study group were significantly better than the control group(P < 0.05).Conclusion The combination of levocarnitine and Yougui Capsule can effectively improve the sex hormone level and sperm quality, improve the reproductive function, which have fewer adverse reactions, and is safe and reliable.
-
Keywords:
- oligospermia in male /
- levocarnitine /
- clinical efficacy /
- asthenospermia /
- Yougui Capsule /
- adverse reactions
-
-
表 1 2组患者治疗总有效率比较[n(%)]
组别 n 治愈 显效 有效 总有效 对照组 40 12(30.0) 14(35.0) 14(35.0) 26(65.0) 研究组 40 23(57.5) 12(30.0) 5(12.5) 35(87.5)* 与对照组比较，*P < 0.05。 
下载: 导出CSV
表 2 2组性激素水平比较(x±s)
组别 时点 T/(ng/dL) FSH/(IU/L) PRL/(ng/mL) P/(ng/mL) LH/(IU/L) 对照组(n=40) 治疗前 574.2±74.9 9.4±4.0 14.3±4.4 0.6±0.3 9.8±3.5 治疗后 778.4±113.2 8.0±2.1 13.7±3.6 0.5±0.4 10.6±2.5 研究组(n=40) 治疗前 572.3±75.3 9.3±3.9 14.5±4.3 0.5±0.3 9.6±3.6 治疗后 812.3±130.2* 9.1±3.5* 13.8±3.7 0.6±0.4 10.8±2.7 T: 血浆睾酮; FSH: 卵泡刺激素; PRL: 催乳素; P: 孕酮; LH: 黄体生成激素。与对照组比较, *P < 0.05。
下载: 导出CSV
表 3 2组患者不良反应发生情况比较[n(%)]
组别 n 口干 便秘 胃肠道不适 肝肾功能损伤 合计 对照组 40 3(7.5) 2(5.0) 3(7.5) 0 8(20.0) 研究组 40 1(2.5) 0 0 0 1(2.5)* 与对照组比较，*P < 0.05。
下载: 导出CSV
表 4 2组精液质量参数比较(x±s)
组别 时点 a级精子/% a级精子+b级精子/% 精子活动率/% 精子密度/(×106/mL) 对照组(n=40) 治疗前 11.0±5.6 30.6±5.5 32.9±6.3 13.6±3.0 治疗后 18.2±9.5 39.2±4.7 65.1±5.4 20.4±6.8 研究组(n=40) 治疗前 11.4±5.8 30.4±5.8 33.2±6.1 13.8±3.2 治疗后 24.2±6.8* 48.1±8.7* 72.5±4.6* 27.1±9.3* 与对照组比较, *P < 0.05。
下载: 导出CSV
-
[1] 蒋远斌, 王铀, 郭宇, 等. 清瘀补精分段论治配合针灸治疗继发性少精弱精症的临床研究[J]. 北京中医药, 2016, 35(2): 148-151. https://www.cnki.com.cn/Article/CJFDTOTAL-BJZO201602018.htm [2] Yapijakis C, Serefoglou Z, Papadimitriou K, et al. High frequency of TTTY2-like gene-related deletions in patients with idiopathic oligozoospermia and azoospermia[J]. Andrologia, 2015, 47(5): 536-544. doi: 10.1111/and.12300
[3] 徐卫兰, 韩东, 邢翠翠. 男性不育症与Y染色体多态性和微缺失关系探讨[J]. 中国优生与遗传杂志, 2018, 26(12): 51-52. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYA201812019.htm [4] 仇占宏, 王星涛, 任旭爱, 等. 参芪扶正注射液联合左卡尼汀对乳腺癌患者术后化疗心肌损伤的保护作用研究[J]. 中国肿瘤临床与康复, 2018, 25(12): 1492-1495. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZK201812030.htm [5] 高章圈, 王淑红, 韩瑞钰, 等. 自拟益肾生精方治疗少弱精不育症的研究[J]. 现代中西医结合杂志, 2018, 27(36): 3991-3994. doi: 10.3969/j.issn.1008-8849.2018.36.001 [6] 韩瑞钰, 邓佩佩, 张展羽, 等. 河北省3378例男性优生遗传咨询分析研究[J]. 中国性科学, 2018, 27(12): 27-30. doi: 10.3969/j.issn.1672-1993.2018.12.008 [7] Vijesh V V, Nambiar V, Mohammed S I, et al. Screening for AZFc partial deletions in Dravidian men with nonobstructive azoospermia and oligozoospermia[J]. Genet Test Mol Biomarkers, 2015, 19(3): 150-155. doi: 10.1089/gtmb.2014.0251
[8] 朱媛媛, 顾万建, 徐天, 等. 男性不育患者精浆miR-551b水平变化及其临床价值[J]. 现代检验医学杂志, 2018, 33(6): 1-4, 8. doi: 10.3969/j.issn.1671-7414.2018.06.001 [9] 汪伟伟, 李鑫, 檀旭东, 等. 利用染色体相对长度分析小Y染色体与少弱精的关系[J]. 解放军医学院学报, 2018, 39(10): 850-852, 865. doi: 10.3969/j.issn.2095-5227.2018.10.004 [10] 涂志华, 杨铭, 马宁, 等. 复方玄驹胶囊联合克罗米芬治疗男性少弱精的疗效及对精液质量的影响分析[J]. 辽宁中医杂志, 2018, 45(8): 1662-1664. https://www.cnki.com.cn/Article/CJFDTOTAL-LNZY201808036.htm [11] 姚佳欣, 陈诗言, 刘青松, 等. 精子细胞XRCC1基因rs25487位点多态性与少弱精患者的相关性研究[J]. 西部医学, 2018, 30(7): 1051-1054, 1059. doi: 10.3969/j.issn.1672-3511.2018.07.025 [12] 王勇, 陈茹, 周瑾, 等. 麒麟丸联合左卡尼汀口服液对少弱精症患者激素水平及精液质量的影响[J]. 现代中西医结合杂志, 2018, 27(21): 2328-2331. doi: 10.3969/j.issn.1008-8849.2018.21.014 [13] Bocedi G, Reid J M. Evolution of female multiple mating: A quantitative model of the "sexually selected sperm" hypothesis[J]. Evolution, 2015, 69(1): 39-58. doi: 10.1111/evo.12550
[14] 连方, 宋诗艳. 右归胶囊通过JAK2/STAT3通路改善高龄体外受精-胚胎移植女性卵细胞质量[J]. 中国中西医结合杂志, 2018, 38(9): 1068-1072. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXJ201809010.htm [15] 赵红娟, 高明, 徐洋涛, 等. 行为干预联合复方玄驹胶囊对不育弱精症患者精液质量的影响[J]. 中国性科学, 2018, 27(6): 29-32. doi: 10.3969/j.issn.1672-1993.2018.06.009
计量
- 文章访问数: 415
- HTML全文浏览量: 212
- PDF下载量: 11
苏公网安备 32100302010246号
