Analysis in detection results of apolipoprotein B and uric acid levels in patients with non-alcoholic fatty liver disease
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摘要:目的 分析非酒精性脂肪肝(NAFLD)患者载脂蛋白B(ApoB)、血清尿酸(SUA)水平的检测结果。方法 将本院收治的150例NAFLD患者纳入研究组，将同期收治的150例体检检查健康人员作为对照组。检测2组患者低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、丙氨酸氨基转移酶(ALT)、腰臀比(WHR)、体质量指数(BMI)、总胆固醇(TC)、ApoB、肌酐(Cr)、血清尿酸(SUA)水平。采用多元Logistic回归分析法分析SUA、ApoB与NAFLD相关性。同时，对2组患者吸烟、冠心病、糖尿病、高血压发生情况进行比较。结果 研究组LDL-C、TG、ALT、WHR、TC、BMI、SUA、ApoB水平均比对照组高，差异有统计学意义(P < 0.05); 研究组Cr水平显著低于对照组，差异有统计学意义(P < 0.05); 多元Logistic回归分析结果显示, SUA、ApoB水平呈独立正相关，是NAFLD的独立危险因素; 研究组吸烟、冠心病、糖尿病、高血压发生率显著高于对照组，差异有统计学意义(P < 0.05)。结论 SUA、ApoB水平与NAFLD病情呈正相关, SUA、ApoB水平越高者心血管疾病发生率越高。因此确诊后应及时进行血脂干预，控制病情。Abstract:Objective To analyze the detection results of apolipoprotein B (ApoB) and serum uric acid (SUA) in patients with non-alcoholic fatty liver disease (NAFLD).Methods A total of 150 NAFLD patients admitted to our hospital were selected as study group, and 150 healthy people with physical examination in the same period were as the control group. Low density lipoprotein cholesterol (LDL-C), triglyceride (TG), alanine aminotransferase (ALT), waist-hip ratio (WHR), body mass index (BMI), total cholesterol (TC), ApoB, creatinine (Cr), SUA levels were measured in the two groups. The correlation between SUA, ApoB and NAFLD was analyzed by multiple Logistic regression analysis. At the same time, smoking, coronary heart disease, diabetes and hypertension were compared between the two groups.Results The levels of LDL-C, TG, ALT, WHR, TC, BMI, SUA and ApoB in the study group were higher than those in the control group (P < 0.05). The levels of Cr in the study group were significantly lower than those in the control group (P < 0.05). The results of multiple Logistic regression analysis showed that the levels of SUA and ApoB were independently and positively correlated with NAFLD and were independent risk factors for NAFLD. The incidences of smoking, coronary heart disease, diabetes mellitus and hypertension were significantly higher than that of the control group (P < 0.05).Conclusion The levels of SUA and ApoB are positively correlated with NAFLD. The higher the levels of SUA and ApoB are, the higher the incidence of cardiovascular disease is. Therefore, blood lipid intervention should be carried out in time to control the development of NAFLD.
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表 1 2组手术效果相关指标对比(x±s)
指标 研究组(n=150) 对照组(n=150) 年龄/岁 56.98±3.65 56.46±3.75 LDL-C/(mmol/L) 2.94±1.29* 2.38±0.45 TG/(mmol/L) 2.13±1.11* 1.51±1.36 ALT/(IU/L) 21.41±10.35* 15.26±6.77 WHR 0.76±0.14* 0.93±0.19 TC/(mmol/L) 5.24±1.27* 4.08±0.69 BMI/(kg/m2) 27.46±2.68* 23.15±1.81 SUA/(μmol/L) 282.86±93.46* 258.56±74.08 ApoB/(mmol/L) 1.11±0.37* 0.95±0.15 Cr/(μmol/L) 0.71±0.14* 0.98±0.17 LDL-C: 低密度脂蛋白胆固醇; TG: 甘油三酯; ALT: 丙氨酸氨基转移酶; WHR: 腰臀比; TC: 总胆固醇; BMI: 体质量指数; SUA: 血清尿酸; ApoB: 载脂蛋白B; Cr: 肌酐。与对照组比较, *P < 0.05。 
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表 2 NAFLD影响因素的Logistic回归分析
指标 SE β Wals P OR 95% CI 常数 2.54 -13.67 29.12 0 0 1.02~22.73 BMI 0.09 0.18 4.01 0.04 1.19 1.01~1.42 SUA 0.99 4.24 16.62 0.02 71.64 1.63~9.98 ApoB 1.09 4.98 18.77 0 82.64 12.45~598.55 BMI: 体质量指数; SUA: 血清尿酸; ApoB: 载脂蛋白B。
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表 3 2组吸烟、冠心病、糖尿病、高血压发生率比较[n(%)]
组别 n 吸烟 冠心病 糖尿病 高血压 研究组 150 78(52.00)* 72(48.00)* 79(52.67)* 112(74.67)* 对照组 150 29(19.33) 27(18.00) 21(14.00) 45(30.00) 与对照组比较, *P < 0.05。
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[1] 樊秀琴, 杨青, 金杭斌, 等. 硒元素对非酒精性单纯性脂肪肝大鼠PPARα、C/EBPα、SREBP-1c及SREBP-2的影响[J]. 中华全科医学, 2019, 17(1): 39-43. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201901012.htm [2] 冯健茹, 许光远. 茵陈蒿汤合四逆散治疗非酒精性脂肪肝伴高同型半胱氨酸血症的临床观察[J]. 中国实验方剂学杂志, 2017, 30(4): 114-126. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201916011.htm [3] 张翠, 黄才发, 范颖超, 等. 血清高尔基体蛋白73对非酒精性脂肪肝肝纤维化的相关性分析[J]. 肝脏, 2018, 23(12): 1133-1134. https://www.cnki.com.cn/Article/CJFDTOTAL-ZUAN201812028.htm [4] 李赓煦. 2型糖尿病患者血尿酸与非酒精性脂肪肝的相关性研究[J]. 世界最新医学信息文摘, 2018, 18(88): 1-4. https://www.cnki.com.cn/Article/CJFDTOTAL-WMIA201888001.htm [5] 张宝, 侯丽丽, 管石侠, 等. 颈围与非酒精性脂肪肝病合并高尿酸血症的关联性分析[J]. 安徽医学, 2018, 39(10): 1239-1241. doi: 10.3969/j.issn.1000-0399.2018.10.020 [6] 郑华龙, 王胜猛, 文志远, 等. 双歧杆菌四联活菌联合多烯磷脂酰胆碱对非酒精性脂肪肝患者糖、脂、尿酸代谢的影响[J]. 广西医科大学学报, 2018, 35(10): 1406-1410. https://www.cnki.com.cn/Article/CJFDTOTAL-GXYD201810020.htm [7] 范玉刚. 血脂、血糖、肝功能和血尿酸联合检测对老年脂肪肝患者的诊断价值[J]. 实用检验医师杂志, 2018, 10(3): 148-151. doi: 10.3969/j.issn.1674-7151.2018.03.008 [8] 程晋芳, 任雅萍, 李学文. 高血压病人非酒精性脂肪肝与血清尿酸的相关性分析[J]. 中西医结合心脑血管病杂志, 2018, 16(13): 1859-1860. doi: 10.12102/j.issn.1672-1349.2018.13.022 [9] 黄文森, 邓少雄, 吴晴翼, 等. ApoB/ApoA1比值及non-HDL-C与2型糖尿病合并非酒精性脂肪肝病的相关性[J]. 山西医科大学学报, 2017, 48(8): 778-782. https://www.cnki.com.cn/Article/CJFDTOTAL-SXYX201708005.htm [10] 谢放, 孟庆华, 侯维, 等. HBeAg阳性慢性乙型肝炎合并非酒精性脂肪肝患者的临床与病理学特征[J]. 中华实验和临床感染病杂志: 电子版, 2018, 12(3): 256-261. doi: 10.3877/cma.j.issn.1674-1358.2018.03.011 [11] 胡燕梅, 丁荣华, 郭英, 等. 非酒精性脂肪肝患者LAP指数、VAI指数、血脂与肾功能关系的临床分析[J]. 宁夏医学杂志, 2018, 22(6): 1-3. https://www.cnki.com.cn/Article/CJFDTOTAL-NXYX201804013.htm
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