摘要:
目的 研究和分析肺炎支原体肺炎(MPP)患儿血清中白细胞介素水平与伴发喘息的相关性.方法 选取136例MPP患儿作为病例组,根据是否伴发喘息将其分为喘息组59例和非喘息组77例,根据病情将喘息组分为急性期组26例和缓解期组33例,选取60例健康儿童作为对照组.对各组患儿及对照组儿童的血清白细胞介素-4 (IL-4)、白细胞介素-5(IL-5)、白细胞介素-13(IL-13)水平进行测定和比较.结果 喘息组、非喘息组、对照组儿童血清IL-4、IL-5、IL-13水平的差异均有统计学意义(F=16.332、112.369、96.411,P＜0.05);急性期组、缓解期组、对照组儿童血清IL-4、IL-5、IL-13水甲的差异均有统计学意义(F =24.058、174.212、143.720,P＜0.05);病例组患儿的血清IL-4水平与IL-5水平呈正相关关系(P＜0.05),而IL-4水平与IL-13水平、IL-5水平与IL-13水平均无相关性(P＞0.05).结论 MPP患儿表现为IL-4、IL-5、IL-13等血清白细胞介素水平的升高.
Abstract:
Objective To study and analyze the correlation between serum levels of interleukins and concomitant wheezing in children with mycoplasma pneumoniae pneumonia (MPP).Methods A total of 136 children with MPP were selected as the case group.The children were divided into the wheezing group (n =59) and the non-wheezing group (n =77).The children in the wheezing group were divided into the acute phase group (n =26) and the remission phase group (n =33) according to the condition of the disease.Sixty healthy children were selected as the control group.The serum interleukin-4 (IL-4),interleukin-5 (IL-5),interleukin-13 (IL-13) levels were detected and compared among all the groups.Results There were significant differences in the serum IL-4,IL-5,IL-13 levels among the wheezing group,the non-wheezing group and the control group (F =16.332,112.369,96.411,P ＜ 0.05).There were significant differences in the serum IL-4,IL-5,IL-13 levels among the acute phase group,the remission phase group and the control group (F =24.058,174.212,143.720,P ＜ 0.05).In the case group,the serum IL-4 level was positively correlated with the IL-5 level (P ＜ 0.05),and there were no correlations between the IL-4 level and the IL-13 level,the IL-5 level and the IL-13 level (P ＞ 0.05).Conclusion The serum expression of IL-4,IL-5 and IL-13 increase in patients with MPP.
百度学术
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