生长分化因子-15在垂体腺瘤中的表达及意义

刘明; 许峥嵘; 刘熙鹏; 张志英; 张秀峰; 曹兵

doi:10.7619/jcmp.201703016

生长分化因子-15在垂体腺瘤中的表达及意义

1.
河北北方学院附属第一医院神经外科,河北张家口,075000;
2.
河北北方学院附属第一医院内分泌科,河北张家口,075000

基金项目: 河北省张家口市科技攻关项目。

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中图分类号: R736.4
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Expression and significance of growth differentiation factor-15 in pituitary adenomas

摘要

摘要: 目的探讨生长分化因子(GDF)-15在垂体腺瘤中的表达及意义.方法选择100例垂体腺瘤患者组织标本,根据是否具有侵袭性分为侵袭性垂体腺瘤63例和非垂体腺瘤37例,并选择同期在本院接受体检的健康人员50例作为对照组.比较各组受试者GDF-15的表达,并分析GDF-15和垂体腺瘤侵袭性的相关性.结果泌乳素垂体腺瘤与生长激素垂体腺瘤患者GDF-15均显著高于无功能性垂体腺瘤患者(P＜0.50);侵袭性垂体腺瘤患者GDF-15水平显著高于非侵袭性组及对照组(P＜0.05);GDF-15和侵袭性垂体腺瘤呈正相关(r=0.328,P=0.001).结论在垂体腺瘤患者中,GDF-15的表达较高,且GDF-15水平和垂体瘤侵袭性存在相关性.
- 生长分化因子-15 /
- 垂体腺瘤 /
- 侵袭性
Abstract: Objective To explore expression and significance of growth differentiation factor (GDF)-15 in pituitary adenomas.Methods A total of 100 tissue samples of patients with pituitary adenomas were selected and divided into invasive pituitary adenomas group (n =63) and non-pituitary adenomas group (n =37) according to aggressive condition,and 50 healthy people were selected as control group.The expression of GDF-15 was compared among the three groups,and the correlation between GDF-15 and the invasiveness of pituitary adenomas was analyzed.Results The level of GDF-15 in patients with prolactin secreting pituitary adenomas and growth hormone adenomas was significantly higher than that of patients with non-functional pituitary adenomas (P ＜ 0.05).The level of GDF-15 in the invasive pituitary adenomas group was significantly higher than the non-invasive group and the control group (P ＜ 0.05).The correlation analysis showed that there was a positive correlation between GDF-15 and invasive pituitary adenomas (r =0.328,P =0.001).Conclusion In patients with pituitary adenomas,the expression of GDF-15 is higher,and there is a correlation between the GDF-15 level and the invasiveness of pituitary adenomas.
- growth differentiation factor-15 /
- pituitary adenoma /
- invasiveness

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生长分化因子-15在垂体腺瘤中的表达及意义

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Expression and significance of growth differentiation factor-15 in pituitary adenomas

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