抗结核药物肝损害对老年肺结核患者血清TNF-α、CG及CA-199水平影响

抗结核药物肝损害对老年肺结核患者血清TNF-α、CG及CA-199水平影响

张琦, 白亚文, 刘钊, 曹思哲, 郭玉琪, 庞健健

文章导航 > 实用临床医药杂志 > 2016 > (21) : 45-47. > DOI: 10.7619/jcmp.201621014

张琦, 白亚文, 刘钊, 曹思哲, 郭玉琪, 庞健健. 抗结核药物肝损害对老年肺结核患者血清TNF-α、CG及CA-199水平影响[J]. 实用临床医药杂志, 2016, (21): 45-47. DOI: 10.7619/jcmp.201621014

引用本文:

张琦, 白亚文, 刘钊, 曹思哲, 郭玉琪, 庞健健. 抗结核药物肝损害对老年肺结核患者血清TNF-α、CG及CA-199水平影响[J]. 实用临床医药杂志, 2016, (21): 45-47. DOI: 10.7619/jcmp.201621014

ZHANG Qi, BAI Yawen, LIU Zhao, CAO Sizhe, GUO Yuqi, PANG Jianjian. Effect of hepatic lesion caused by anti-tuberculosis drugs on serum levels of TNF-α, CG and CA-199 in elderly patients with pulmonary tuberculosis[J]. Journal of Clinical Medicine in Practice, 2016, (21): 45-47. DOI: 10.7619/jcmp.201621014

Citation:

ZHANG Qi, BAI Yawen, LIU Zhao, CAO Sizhe, GUO Yuqi, PANG Jianjian. Effect of hepatic lesion caused by anti-tuberculosis drugs on serum levels of TNF-α, CG and CA-199 in elderly patients with pulmonary tuberculosis[J]. Journal of Clinical Medicine in Practice, 2016, (21): 45-47. DOI: 10.7619/jcmp.201621014

抗结核药物肝损害对老年肺结核患者血清TNF-α、CG及CA-199水平影响

1.
陕西省西安市胸科医院内七科,陕西西安,710061;
2.
陕煤化集团铜川矿务局中心医院感染科,陕西铜川,727000

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Effect of hepatic lesion caused by anti-tuberculosis drugs on serum levels of TNF-α, CG and CA-199 in elderly patients with pulmonary tuberculosis

摘要: 目的探讨抗结核药物肝损害对老年肺结核患者外周血肿瘤坏死因子-α (TNF-α)、甘胆酸(CG)及糖类抗原199(CA-199)水平的影响及与肝损害相关指标的相关性.方法 34例因服用抗结核药物出现药物肝损害肺结核患者设为观察组,32例老年健康人群作为对照组.结果观察组患者血清中TBIL、ALT及ALP水平显著高于对照组(P＜0.05);观察组患者血清中TNF-α、CG及CA-199水平显著高于对照组(P＜0.05).观察组患者血清中TNF-α、CG及CA-199水平与ALT均呈正相关(P＜0.05).结论抗结核药物肝损害可促进老年肺结核患者血清中TNF-α、CG及CA-199的表达.
- 老年 /
- 肺结核 /
- 肝损害 /
- 抗结核药物
- elderly /
- pulmonary tuberculosis /
- hepatic lesion /
- anti tuberculosis drugs

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